Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/225983
Title: Complexation Of Transition Metal Ions With Some Antibiotics A Potentiometric Study
Researcher: Bhardwaj, N
Guide(s): M K Singh
University: Dr. C.V. Raman University
Completed Date: 2014
Abstract: The present study comprises determination of stability constant and the thermodynamics of interaction of Fluoroquinolones antibiotics, Flumequine, Ciprofloxacin, Levofloxacin and Sparfloxacin with transition metal Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) ions. Among the outstanding achievement of human being is the discovery of antibiotics. It is called miracle drugs for its effectiveness and efficiency is controlling several diseases in plants, animals and human beings. Metal ion have many important functions in biological system so detailed physicochemical investigation of the metal complexation with antibiotics is worth study. The association of the metal with ligands produces observable changes in the chemistry of both the metal ion and the ligand and hence changes in various physical and chemical properties. A wide variety of physical methods have been applied to the study of metal ligand interactions. Potentiometric pH titration technique is the most convenient and versatile method. In this method, the substance is titrated with alkali twice, first in the absence and then in the presence of the metal ion. Because the metal cation displaces the hydrogen cation, the second titration curve lies at lower pH-value than the first one. The difference between these curves can be used for the calculation of proton and metal stability constant of ligands employing some mathematical calculations. The formation of 1:1 and 1:2 metal ligand complexes are found to be formed in 50 %( v/v) methanol water system for each case. The stability constant values for metal-ligand system compared at three temperatures, it is found that value of stability constant decreases with increasing temperature. newline
URI: http://hdl.handle.net/10603/225983
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title.pdf114.7 kBAdobe PDFView/Open
02_declaration.pdf196.73 kBAdobe PDFView/Open
03_certificate.pdf141.98 kBAdobe PDFView/Open
04_acknowledgement.pdf143.15 kBAdobe PDFView/Open
05_list of figures.pdf482.49 kBAdobe PDFView/Open
06_abbriviations.pdfAttached File216.11 kBAdobe PDFView/Open
07_list of tables.pdf402.55 kBAdobe PDFView/Open
08_abstract.pdf110.38 kBAdobe PDFView/Open
09_chapter 1.pdf510.39 kBAdobe PDFView/Open
10_chapter 2.pdf212.26 kBAdobe PDFView/Open
11_chapter 3.pdf530.04 kBAdobe PDFView/Open
12_chapter 4.pdf2.22 MBAdobe PDFView/Open
13_chapter 5.pdf2.21 MBAdobe PDFView/Open
14_chapter 6.pdf2.21 MBAdobe PDFView/Open
15_chapter 7.pdf2.21 MBAdobe PDFView/Open
16_chapter 8.pdf452.42 kBAdobe PDFView/Open
17_bibliography.pdf179.59 kBAdobe PDFView/Open
18_paper published.pdf117.99 kBAdobe PDFView/Open
19_graph - table landscape.pdf1.92 MBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetric Badge: