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Title: Chiral separation of drugs and drug intermediates by immobilized biocatalyst
Researcher: Vaidya, Bhalchandra K
Guide(s): Kulkarni, Bhaskar D
Keywords: Biotechnology, Chemical Engineering
Upload Date: 17-Aug-2011
University: University of Pune
Completed Date: December, 2009
Abstract: Chirality has become a major theme in the design, discovery, development and marketing of new drugs. The role of chirality in efficacy and safety of drugs has been thoroughly identified and implicated globally by pharmaceutical industries as well as concerned regulatory agencies. Thus, in order to accomplish efficacious and safe medication and also compliance with the guidelines set by the regulatory agencies, pharmaceutical industries are compelled to move towards manufacturing and marketing of chiral drugs essentially in single-enantiomer dosage forms. The worldwide sales of chiral drugs in single-enantiomer dosage forms continued growing at about 13% annual rate over past few years. To respond the rising industrial demand of enantiopure drugs, search of new efficient methods of asymmetric synthesis and the strategic development of the available methods have been the center-stage of academic as well as industrial pharmaceutical research over the recent years. Employing enzymes (biocatalysts) for enantioselective organic synthesis in last decade, proved to be a valuable alternative to conventional chemical methods. Enzymes quite often display high chemo-, regio-, and enantioselctivity, which make them attractive catalysts especially for pharmaceuticals, where the demand for enantiomerically pure molecules is continuously rising. Enzyme-catalyzed reactions are carried out generally under mild conditions (with respect to temperature, pressure and pH) that minimize problems like isomerization, racemization or epimerization of product.
Pagination: 259p.
Appears in Departments:Chemical Engineering and Process Development Division

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02_certificate.pdf29.65 kBAdobe PDFView/Open
03_declaration.pdf14.65 kBAdobe PDFView/Open
04_dedication.pdf20.54 kBAdobe PDFView/Open
05_contents.pdf105.14 kBAdobe PDFView/Open
06_acknowledgements.pdf82.81 kBAdobe PDFView/Open
07_list of abbreviation.pdf164.82 kBAdobe PDFView/Open
08_list of figures.pdf130.09 kBAdobe PDFView/Open
09_list of schemes.pdf143.75 kBAdobe PDFView/Open
10_list of tables.pdf139.62 kBAdobe PDFView/Open
11_chapter 1.pdf626.94 kBAdobe PDFView/Open
12_chapter 2.pdf708.09 kBAdobe PDFView/Open
13_chapter 3.pdf385.62 kBAdobe PDFView/Open
14_chapter 4.pdf701.82 kBAdobe PDFView/Open
15_chapter 5.pdf411.84 kBAdobe PDFView/Open
16_chapter 6.pdf697.7 kBAdobe PDFView/Open
17_chapter 7.pdf317.62 kBAdobe PDFView/Open
18_chapter 8.pdf168.35 kBAdobe PDFView/Open
19_abstract.pdf23.14 kBAdobe PDFView/Open

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