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Title: Action of chemotherapeutic drugs-molecular mechanism and role of signaling molecules at cellular level
Researcher: Kumar, Ankur
Guide(s): Bhat, Manoj Kumar
Keywords: Biotechnology, Chemotherapeutic drugs, Signaling molecules
Upload Date: 17-Aug-2011
University: University of Pune
Completed Date: July, 2008
Abstract: The response rates of extensively used chemotherapeutic drugs are relatively disappointing because of considerable side effects associated with their high-dose regimen and due to the lack of specificity towards their respective molecular target. Aim of the present study is to offer a better and more rational approach to cancer chemotherapeutic treatment. Hence the primary objective of present study is to identify some compounds/drugs, which show additive or synergistic cytotoxic effects or enhance the drug uptake in combination with other conventional cytotoxic drugs to facilitate reduction of drug dosage. In addition to investigate the functions of some important regulatory proteins, present study also aims to explore novel targets of drug(s) and their involvement in the induction of cell death initiated by different chemotherapeutic drugs in breast cancer cells. One of the objectives of the present study was to enhance the efficacy of low concentrations of Carboplatin (Carb) or 5-Fluorouracil (5-FU).
Pagination: 153p.
Appears in Departments:National Centre for Cell Science

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01_title.pdfAttached File106.46 kBAdobe PDFView/Open
02_dedication.pdf86.59 kBAdobe PDFView/Open
03_table of contents.pdf152.78 kBAdobe PDFView/Open
04_acknowledgments.pdf76.45 kBAdobe PDFView/Open
05_certificate.pdf130.59 kBAdobe PDFView/Open
06_declaration.pdf130.75 kBAdobe PDFView/Open
07_abbreviations and symbols.pdf84.33 kBAdobe PDFView/Open
08_abstract.pdf109.41 kBAdobe PDFView/Open
09_part-1.pdf983.58 kBAdobe PDFView/Open
10_part-2.pdf281.88 kBAdobe PDFView/Open
11_part-3.pdf1.12 MBAdobe PDFView/Open
12_part-4.pdf641.41 kBAdobe PDFView/Open
13_part-5.pdf558.37 kBAdobe PDFView/Open
14_references.pdf108.54 kBAdobe PDFView/Open
15_appendix.pdf176.05 kBAdobe PDFView/Open

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