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Title: Inhibition of IL-2 induced IL-10 production as a principle of phase specific immuno-therapy for visceral leishmaniasis
Researcher: Bodas, Manish
Guide(s): Saha, Bhaskar
Keywords: Biotechnology, Cell Science, Immuno therapy, Visceral Leishmaniasis
Upload Date: 17-Aug-2011
University: University of Pune
Completed Date: September, 2006
Abstract: Visceral leishmaniasis is a fatal disease caused by the protozoan parasite Leishmania donovani. T cells are known to mediate resistance or susceptibility against this ‘neglected disease’ by the intricate cytokine milieu created by these cells during infection with L. donovani. Progression of visceral leishmaniasis is characterized by suppression of anti-leishmanial T cell responses, which was thought to be due to deficiency of interleukin-2, a potent T cell growth factor. The present study defies this to some extent, showing that during the first week of L. donovani infection, IL-2 induces IL-10 from antigen-primed T cells which suppresses the host-protective functions of infiltrating naïve T cells, in the later phase of infection. Host protection could be achieved by neutralizing IL-2/IL-2R and IL-10 at different time points after infection, which demonstrates their distinct roles at the priming and effector phases. This establishes a novel strategy of using kinetic modulation of an ongoing immune response as a principle of phase-specific immunotherapy for visceral leishmaniasis.
Pagination: 140p.
Appears in Departments:National Centre for Cell Science

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02_certificate.pdf70.63 kBAdobe PDFView/Open
03_declaration.pdf71.75 kBAdobe PDFView/Open
04_dedication.pdf92.71 kBAdobe PDFView/Open
05_acnowledgement.pdf68.66 kBAdobe PDFView/Open
06_contents.pdf82.98 kBAdobe PDFView/Open
07_abbreviations.pdf130.96 kBAdobe PDFView/Open
08_abstract.pdf53.19 kBAdobe PDFView/Open
09_chapter 1.pdf659.75 kBAdobe PDFView/Open
10_chapter 2.pdf50.45 kBAdobe PDFView/Open
11_chapter 3.pdf271.1 kBAdobe PDFView/Open
12_chapter 4.pdf703.94 kBAdobe PDFView/Open
13_chapter 5.pdf113.59 kBAdobe PDFView/Open
14_appendix.pdf84.08 kBAdobe PDFView/Open
15_list of publication.pdf53.15 kBAdobe PDFView/Open
16_references.pdf245.64 kBAdobe PDFView/Open

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