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Title: A comparative study of α-Hemolysin and Jacalin that influence mammalian cell signaling
Researcher: Pany, Satyabrata
Guide(s): Bhat, Manoj Kumar
Keywords: Cell Science, Cell Signalings, Biotechnology, Mammals
Upload Date: 17-Aug-2011
University: University of Pune
Completed Date: January, 2008
Abstract: To overcome host cell defense and for pathogenesis, pathogenic bacteria secrete soluble factors to interact and interfere with essential host systems. Most of these soluble factors are known as pore forming toxins and likely to be the primary virulence factors. They modulate host cell signaling or damage host cell membranes by pore formation upon binding to susceptible target cells. Staphylococcus aureus bacteria secrete a soluble pore forming toxin “α-hemolysin”, which follows a multi-step oligomerization process to assemble into a heptameric functional pore on the target or host cell membrane after binding. Membrane binding of α-HL and its oligomerization into heptameric pore either modulates host cell signaling or permeabilizes the target cells. Although α-HL binds to virtually all mammalian cells but also shows cell tropism dependent differential membrane recognition. Differential membrane recognition compels us to believe that α-HL may bind to specific receptor(s) on susceptible host membrane for its action. But the eukaryotic cell micro-domain (lipid raft/caveolae) specific receptor(s) or molecules that aid susceptibility dependent membrane recognition and assembly of α-HL was not ascertained. Here we studied the molecular basis of differential membrane recognition domain of α-HL and how it exploits eukaryotic membrane receptor for assembly and modulation of mammalian cell signaling.
Pagination: 128p.
Appears in Departments:National Centre for Cell Science

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01_title.pdfAttached File135.26 kBAdobe PDFView/Open
02_note.pdf171.89 kBAdobe PDFView/Open
03_dedication.pdf94.34 kBAdobe PDFView/Open
04_contents.pdf180.62 kBAdobe PDFView/Open
05_acknowledgements.pdf94.16 kBAdobe PDFView/Open
06_declaration.pdf109.45 kBAdobe PDFView/Open
07_certificate.pdf108.87 kBAdobe PDFView/Open
08_preface.pdf147.22 kBAdobe PDFView/Open
09_abstract.pdf140.63 kBAdobe PDFView/Open
10_abbreviations and symbols.pdf123.54 kBAdobe PDFView/Open
11_chapter 1.pdf1.03 MBAdobe PDFView/Open
12_chapter 2.pdf520.66 kBAdobe PDFView/Open
13_chapter 3.pdf645.78 kBAdobe PDFView/Open
14_chapter 4.pdf490.81 kBAdobe PDFView/Open
15_chapter 5.pdf265.18 kBAdobe PDFView/Open
16_references.pdf147.87 kBAdobe PDFView/Open

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