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Title: Chemopreventive Effects of Bee Propolis and its Constituents on Hepatocarcinogenesis and their Role in Modulation of Methotrexate toxicity
Researcher: Nemat Ali
Guide(s): Sarwat Sultana
Keywords: Life Sciences; Propolis; Bee products; Hepatocarcinogenesis; Neoplasms; ethotrexate
University: Jamia Hamdard University
Completed Date: 2015
Abstract: The main emphasis of this thesis is the assessment of therapeutic potential of naturally occurring plant product, Bee Propolis and its constituents namely chrysin and chlorogenic acid against hepatotoxicity induced by Methotrexate (MTX), an anticancer drug in animal model as well as the role of bee Propolis and its constituents, chrysin and chlorogenic acid was evaluated against DEN initiated and 2-AAF promoted 2 stage hepatocarcinogenesis model in Wistar Rats. newlineThe results of our thesis supported by strong published literature reports suggest these natural compounds to be a potential candidate for prevention of chemically induced hepatotoxicity and hepatocarcinogenesis, since they restrain numerous biomarkers of oxidative stress, inflammation, apoptosis and tumor promotion in wistar rats. Further detailed mechanistic studies are necessary to reveal the useful effect of these naturally compounds before proceeding for clinical trials. newline
Appears in Departments:Department of Medical Elementology and Toxicology

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abbrevations and symbols.pdfAttached File53.53 kBAdobe PDFView/Open
bibleography.pdf1.19 MBAdobe PDFView/Open
chapter 1.pdf990.81 kBAdobe PDFView/Open
chapter iii.pdf2.98 MBAdobe PDFView/Open
chapter ii .pdf281.97 kBAdobe PDFView/Open
chapter iv.pdf1.18 MBAdobe PDFView/Open
chapter v .pdf1.07 MBAdobe PDFView/Open
summary .pdf236.11 kBAdobe PDFView/Open
title page.doc403.99 kBMicrosoft WordView/Open
toc.doc99.09 kBMicrosoft WordView/Open

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