Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/220945
Title: Pharmacological and Toxicological Evaluation of Indian Noni in Animal Models of Psychiatric Disorders
Researcher: Srikanth J
Guide(s): Kavimani S
Keywords: Clinical Pre Clinical and Health
University: Sri Ramachandra University
Completed Date: 29/10/2018
Abstract: Morinda citrifolia fruit extract was evaluated in vivo for treatment of OCD in behavioural animal models like Marble burying behaviour test and nestlet shredding test It may be concluded that the Morinda citrifolia fruit extract produced an anti OCD like activity that seems to be dependent on its interaction with the serotonergic noradrenergic and dopaminergic systems as evident from the brain monoamine estimation The neuroprotective activity of MCFE was identified by both in vitro and ex vivo techniques by acetylcholinesterase inhibition and glutamate induced neurotoxicity assay In vitro and in vivo toxicological evaluation was performed by Brine shrimp lethality assay and Fish Acute Toxicity study respectively No acute toxicity effects were associated with Morinda citrifolia fruit extract Ex vivo toxicological evaluation of MCFE was performed by evaluating serum haematology and clinical biochemical parameters There was no evidence of toxicity produced in histopathological evaluation of vital organs of treated animals for a period of fifteen days newline
Pagination: 1-167
URI: http://hdl.handle.net/10603/220945
Appears in Departments:College of Pharmacy

Files in This Item:
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10. summary and conclusion.pdfAttached File445.52 kBAdobe PDFView/Open
11. future perspectives.pdf543.52 kBAdobe PDFView/Open
12. appendix.pdf3.06 MBAdobe PDFView/Open
1.title.pdf404.18 kBAdobe PDFView/Open
2. certificate.pdf740.01 kBAdobe PDFView/Open
3. preliminary pages.pdf811.64 kBAdobe PDFView/Open
4. introduction.pdf1.35 MBAdobe PDFView/Open
5. aim and objectives.pdf521.04 kBAdobe PDFView/Open
6. plan of work.pdf543.43 kBAdobe PDFView/Open
7. review of literature.pdf920.26 kBAdobe PDFView/Open
8. materials and methods.pdf2.01 MBAdobe PDFView/Open
9. results and discussion.pdf3.28 MBAdobe PDFView/Open


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