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Title: Design development and characterization of a novel ocular niosomal in situ gel for reduction in intra ocular pressure
Researcher: Nagalakshmi S
Guide(s): Damodharan N
Keywords: Clinical Pre Clinical and Health
Gelling capacity
In situ gel
Thin film hydration
University: Sri Ramachandra University
Completed Date: 20/10/2018
Abstract: Conventional dosage forms commonly used in treating glaucoma through some conventional dosage forms result in few disadvantages like short residence time frequent instillation and poor patient compliance The aim of the present study is to formulate and evaluate a novel ocular niosomal in situ gel based drug delivery system commonly used in treating glaucoma Thin film hydration technique was used in preparing niosomes by using cholesterol and surfactant in different molar ratio An extensive optimization of formulations was done by using different ratios of surfactant keeping cholesterol and drug as constant They were evaluated for particle size entrapment efficiency drug content and in vitro release studies The optimized formulation was developed into niosomal in situ gel using carbopol and HPMC low and high viscous polymers in different ratios and evaluated for gelling capacity pH viscosity in-vitro drug release drug content sterility test stability studies kinetics ex-vivo transcorneal permeation and HET CAM irritation studies Niosomal in situ gels showed no irritation potential by in vivo animal studies Hence the developed niosomal in situ gel was found to be an excellent alternate to the existing conventional formulations by virtue of reducing dosing frequency improved bioavailability and better patient acceptance newline
Pagination: 1-192
Appears in Departments:College of Pharmacy

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