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dc.description.abstractPolycystic ovary syndrome (PCOS), the most common endocrine disorder affecting women of reproductive age is associated with state of low grade chronic inflammation and depends on multiple genetic and environmental factors. Intercellular adhesion molecule-1 (ICAM-1) is an important biomarker of inflammation and endothelial dysfunction.Elevated levels of inflammatory markers including ICAM-1 are demonstrated in women with PCOS suggesting increased cardiovascular risk in these women.Recent evidence indicates a significant linkage between chromosome 19p13 loci and multifactorial diseases that have an inflammatory involvement.ICAM-1 gene located on chromosome 19p13 has genetic variations which are common in populations and many studies have described associations between these polymorphisms and inflammatory disease. Therefore, the polymorphism of ICAM-1 gene represents a strong positional and biological candidate for the susceptibility to the development of inflammatory and metabolic diseases which includes PCOS. In the present study the possible role of K469E polymorphism on exon 6 and G241R polymorphism on exon 4 of ICAM -1 gene in development of PCOS among Kashmiri (North Indian) women has been examined. newlineOral contraceptive pills (OCP s), are the usual first choice of treatment, after weight reduction and lifestyle modifications in women with PCOS, as they ameliorates hyperandrogenic symptoms. Because OCP s are known to alter coagulation and fibrinolytic markers towards a more hypercoagulable state and epidemiological studies have shown increased risk for venous thromboembolism among users of OCP s compared to non- user. Therefore treatment with OCP s may worsen the already deranged inflammatory and coagulation parameters in this population. In this study effect of administration of OCP s (0.03mg- ethinyl-estradiol and 0.15mg- levonogestrel) on mRNA expression of ICAM-1 gene in women with PCOS was examined. The results may translate into better management in clinical practice...
dc.titleEvaluation of Variants of ICAM1 Gene in Kashmiri Polycystic Ovary Syndrome PCOS Women and its Comparative Expression Analysis with and without Usage of Oral Contraceptive Pills OCPs
dc.creator.researcherSyed, Douhath Yousuf
dc.subject.keywordICAM-1 gene
dc.subject.keywordPolycystic ovary syndrome
dc.contributor.guideFouzia Rashid; Zargar, Mohammad Afzal; Ganie, Mohammad Ashraf
dc.publisher.placeJammu and Kashmir
dc.publisher.universityUniversity of Kashmir
dc.publisher.institutionDepartment of Biochemistry
Appears in Departments:Department of Biochemistry

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02_certificate.pdf248.48 kBAdobe PDFView/Open
03_abstract.pdf286.72 kBAdobe PDFView/Open
04_declaration.pdf247.54 kBAdobe PDFView/Open
05_dedication.pdf214.43 kBAdobe PDFView/Open
06_acknowledgement.pdf297.4 kBAdobe PDFView/Open
07_contents.pdf351.15 kBAdobe PDFView/Open
08_abbreviations.pdf346.71 kBAdobe PDFView/Open
09_list_of_figures.pdf240.9 kBAdobe PDFView/Open
10_list_of_tables.pdf223.66 kBAdobe PDFView/Open
11_introduction.pdf304.07 kBAdobe PDFView/Open
12_review_of_literature.pdf1.56 MBAdobe PDFView/Open
13_reseach_methodology.pdf508.77 kBAdobe PDFView/Open
14_results.pdf2.22 MBAdobe PDFView/Open
15_discussion.pdf427.47 kBAdobe PDFView/Open
16_conclusion.pdf232.68 kBAdobe PDFView/Open
17_bilbiography.pdf860.74 kBAdobe PDFView/Open
18_appendix.pdf240.63 kBAdobe PDFView/Open
19_publications.pdf1 MBAdobe PDFView/Open

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