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Title: Synthesis and Biological Evaluation of Indole and Thienopyrimidine Derivatives as 5-HT6 Receptor Ligands
Researcher: Prabhakar, K
Guide(s): Ramakrishna, N V S
Dubey, P K
Keywords: Biological
Upload Date: 23-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: The theme of the research work is design and synthesis of novel molecules which have potent affinity towards 5-HT 6 receptors. Based on this concept, design and synthesis of novel 5-(N-substituted piperazinyl)- newlineN1-aryl (sulfonyl, carbonyl and methylene) indole derivatives and fused thieno pyrimidine derivatives were undertaken and evaluated the in-vitro activity of these derivatives. 5-(N-substituted piperazinyl)-N1-arylsulfonyl indoles were found to have potent affinity towards 5-HT 6 receptors. So newlinethese derivatives were further taken up for their evaluation in in-vivo studies. They have good selectivity over other receptors and no CYP liabilities. These derivatives were further profiled in animal models of newlinecognition like Novel Object Recognition Test (NORT) and Morris water maze. Oral administration of these compounds has shown improvement in performance of rats in NORT and significantly reversed scopolamine newlineinduced special memory deficit in Morris water maze test indicating improvement in cognitive potential of the compounds. newline
Pagination: 218
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File135.93 kBAdobe PDFView/Open
02_declaration.pdf61.65 kBAdobe PDFView/Open
03_certificate.pdf63.32 kBAdobe PDFView/Open
04_acknowledgement.pdf87.39 kBAdobe PDFView/Open
05_dedication.pdf90.22 kBAdobe PDFView/Open
06_abstract.pdf95.55 kBAdobe PDFView/Open
07_contents.pdf94.53 kBAdobe PDFView/Open
08_list of publications & tables.pdf120.1 kBAdobe PDFView/Open
09_chapter 1.pdf693.46 kBAdobe PDFView/Open
10_chapter 2.pdf252.85 kBAdobe PDFView/Open
11_chapter 3.pdf195.43 kBAdobe PDFView/Open
12_chapter 4.pdf174.2 kBAdobe PDFView/Open
13_chapter 5.pdf185.47 kBAdobe PDFView/Open
14_chapter 6.pdf289.09 kBAdobe PDFView/Open
15_chapter 7.pdf214.11 kBAdobe PDFView/Open
16_references.pdf183.05 kBAdobe PDFView/Open

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