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dc.description.abstractThe coupling of an olefin with a carbonyl compound in the presence of an acid catalyst is newlineknown as the Prins reaction which normally provides a mixture of 1, 3-diols, 1, 3- newlinedioxanes, and allylic alcohols. In particular, the coupling of a homoallylic alcohol with a newlinecarbonyl compound in the presence of an acid catalyst is known as the Prins newlinecyclization , which is a powerful synthetic tool for the stereo selective synthesis of newlinetetrahydropyran scaffolds. On the other hand, aza-Prins cyclization of homoallylic amides newlinewith carbonyl compounds is one of the most elegant approaches for the synthesis of newlinepiperidine derivatives. In the same way, thia-Prins cyclization of homoallylic mercaptans newlinewith aldehydes under the influence of an acid catalyst provides the corresponding newlinethiotetrahydropyrans with a high selectivity. Thus, the Prins cyclization has emerged as a newlinepowerful method for the stereo selective synthesis of a wide range of heterocycles such as newlinetetrahydropyran, piperidine and thiotetrahydropyran scaffolds (Scheme-2). Many newlineresearch groups including work from our group have broadened the scope of Prins newlinecyclization via development of new methodologies (Scheme-1). newline
dc.titleTotal Synthesis of Biologically Active Natural Products Using Prins Cyclization Approach and Development of Novel Synthetic Methodlogies
dc.creator.researcherBiradar Dhanraj Omprakash
dc.contributor.guideYadav J.S.
dc.publisher.universitySwami Ramanand Teerth Marathwada University
dc.publisher.institutionSchool of Chemical Sciences
Appears in Departments:School of Chemical Sciences

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02_ceritificate.pdf576.42 kBAdobe PDFView/Open
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05_acknowledgement.pdf157.67 kBAdobe PDFView/Open
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09_abbreviations.pdf152.24 kBAdobe PDFView/Open
10 _ chapter 1.pdf7.88 MBAdobe PDFView/Open
11 _ chapter 2.pdf5.12 MBAdobe PDFView/Open
12_ chapter 3.pdf4.36 MBAdobe PDFView/Open
3_abstract.pdf2.22 MBAdobe PDFView/Open

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