Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/193666
Title: Total Synthesis of Biologically Active Natural Products Using Prins Cyclization Approach and Development of Novel Synthetic Methodlogies
Researcher: Biradar Dhanraj Omprakash
Guide(s): Yadav J.S.
Keywords: n.a.
University: Swami Ramanand Teerth Marathwada University
Completed Date: 2017
Abstract: The coupling of an olefin with a carbonyl compound in the presence of an acid catalyst is newlineknown as the Prins reaction which normally provides a mixture of 1, 3-diols, 1, 3- newlinedioxanes, and allylic alcohols. In particular, the coupling of a homoallylic alcohol with a newlinecarbonyl compound in the presence of an acid catalyst is known as the Prins newlinecyclization , which is a powerful synthetic tool for the stereo selective synthesis of newlinetetrahydropyran scaffolds. On the other hand, aza-Prins cyclization of homoallylic amides newlinewith carbonyl compounds is one of the most elegant approaches for the synthesis of newlinepiperidine derivatives. In the same way, thia-Prins cyclization of homoallylic mercaptans newlinewith aldehydes under the influence of an acid catalyst provides the corresponding newlinethiotetrahydropyrans with a high selectivity. Thus, the Prins cyclization has emerged as a newlinepowerful method for the stereo selective synthesis of a wide range of heterocycles such as newlinetetrahydropyran, piperidine and thiotetrahydropyran scaffolds (Scheme-2). Many newlineresearch groups including work from our group have broadened the scope of Prins newlinecyclization via development of new methodologies (Scheme-1). newline
Pagination: 143p
URI: http://hdl.handle.net/10603/193666
Appears in Departments:School of Chemical Sciences

Files in This Item:
File Description SizeFormat 
01_title.pdfAttached File30.65 kBAdobe PDFView/Open
02_ceritificate.pdf576.42 kBAdobe PDFView/Open
04_declaration.pdf67.66 kBAdobe PDFView/Open
05_acknowledgement.pdf157.67 kBAdobe PDFView/Open
06_contents.pdf90.19 kBAdobe PDFView/Open
07_list_of_tables.pdf11.86 kBAdobe PDFView/Open
08_list_of_figures.pdf26.38 kBAdobe PDFView/Open
09_abbreviations.pdf152.24 kBAdobe PDFView/Open
10 _ chapter 1.pdf7.88 MBAdobe PDFView/Open
11 _ chapter 2.pdf5.12 MBAdobe PDFView/Open
12_ chapter 3.pdf4.36 MBAdobe PDFView/Open
3_abstract.pdf2.22 MBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetric Badge: