Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/19365
Title: Synthesis and Biological Evaluation of Arylsulfonamides and Indole Derivatives as Serotonin 5-HT6 Receptor Ligands
Researcher: Daulatabad, Anand Vijaykumar
Guide(s): Ramakrishna, N V S
Dubey, P K
Keywords: Arylsulfonamides
Biological
Evaluation
Ligands
Serotonin
Synthesis
Upload Date: 17-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: ABSTRACT OF THE THESIS ENTITLED SYNTHESIS AND BIOLOGICAL EVALUATION OF ARYLSULFONAMIDES AND INDOLE DERIVATIVES AS SEROTONIN 5-HT 6 RECEPTOR LIGANDS newlineThe work presented in this thesis explores novel chemical series as GPCR ligands, especially as 5-HT 6 receptor ligands. The embodied work is an attempt to address the challenging medical requirements in the newlinefield of central nerous system (CNS) disorders, especially Alzheimers disease. These presented chemical serises were achieved through understanding of basic pharmacophoric requirements to get 5-HT 6 newlinereceptor activity in combination with structure based designing. The modifications were carried out on the basis of in-vitro and in-vivo results. The basic criteria for molecules designed in the presented serises was that, the molecules should have reasonable binding affinity towards 5- newlineHT 6 receptor with high selectivity (no nteraction with other closely related receptors), it should have acceptable cytochrome P450 liabilities, good metabolic stability and brain penetrative capabilities along with adequate systemic exposure. The other important criterion was that, the newlinecompound should also have activity in animal models of cognition like Morris Water Maze or Novel Object Recognition Task (NORT). The thesis is divided into six chapters and brief details are presented below. newline
Pagination: 227 p.
URI: http://hdl.handle.net/10603/19365
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title.pdfAttached File98.4 kBAdobe PDFView/Open
02_declaration.pdf59.8 kBAdobe PDFView/Open
03_certificate.pdf66.15 kBAdobe PDFView/Open
04_acknowledgement.pdf89.65 kBAdobe PDFView/Open
05_dedication.pdf28.37 kBAdobe PDFView/Open
06_abstract.pdf132.29 kBAdobe PDFView/Open
07_contents.pdf97.3 kBAdobe PDFView/Open
08_abbreviation.pdf63.41 kBAdobe PDFView/Open
09_chapter 1.pdf425.85 kBAdobe PDFView/Open
10_chapter 2.pdf311.18 kBAdobe PDFView/Open
11_chapter 3.pdf329.69 kBAdobe PDFView/Open
12_chapter 4.pdf369.29 kBAdobe PDFView/Open
13_chapter 5.pdf510.89 kBAdobe PDFView/Open
14_chapter 6.pdf335.34 kBAdobe PDFView/Open
15_references.pdf155.24 kBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.