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Title: New reactive iron carbonyl reagents for applications in organic synthesis
Researcher: Rameshkumar, C
Guide(s): Periasamy, M
Upload Date: 7-Apr-2011
University: University of Hyderabad
Completed Date: 24/04/2000
Abstract: This thesis describes studies on the "New Reactive Iron Carbonyl Reagents for Applications in Organic Synthesis". It comprises of three chapters. Each chapter is subdivided into four parts, namely Introduction, Results and Discussion, Conclusions and Experimental Section along with References. The work described in this thesis is exploratory in nature and the chapters are arranged in the order the investigations were executed. The first chapter describes the investigations on the reactions of alkynes with iron carbonyl species, prepared in situ using Fe(CO)5/NaBH4/CH3COOH and Fe3(CO)12/amine systems. In the introductory section, a brief review on the methods of preparation and synthetic applications of the readily accessible Fe(CO)5, Fe2(CO)9, Fe3(CO)12, Na2Fe(CO)4, HFe(CO)4\ HFe2(CO)8\ [HFe3(CO)u]\ H2Fe(CO)4, H2Fe3(CO)n and the coordinatively unsaturated iron carbonyl species such as "Fe(CO)4", and "Fe2(CO)8" are presented. Previously, it was observed in this laboratory that the reactive iron carbonyl species, prepared using the HFe(CO)47RX (RX - CH3I or Me3SiCl) combination, on reaction with alkynes followed by CuCl2.2H2O oxidation gives cyclobutenediones in moderate to good yields. The U.V spectra recorded for the iron carbonyl species, prepared using the Fe(CO)5/NaBH4/CH3COOH and the NaHFe(CO)4/RX (RX - CH3I, CH2CI2 and Me3SiCl) reagent combinations, exhibit characteristic X ^ in solution in the region reported for [HFe3(CO)n]7H2Fe3(CO)ii species. The reaction of alkynes with the iron carbonyl species [HFe3(CO)n]\ prepared in situ by the reduction of Fe(CO)s using NaBH* in the presence of excess CH3COOH in THF, gives the corresponding cyclobutenediones in good yields (60- 73%) after CuCl2.2H2O oxidation (Scheme 1).
Pagination: vi, 176p.
Appears in Departments:School of Chemistry

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01_title.pdfAttached File17.12 kBAdobe PDFView/Open
02_dedication.pdf11.74 kBAdobe PDFView/Open
03_contents.pdf16.78 kBAdobe PDFView/Open
04_statement.pdf16.72 kBAdobe PDFView/Open
05_certificate.pdf17.49 kBAdobe PDFView/Open
06_acknowledgements.pdf28.29 kBAdobe PDFView/Open
07_abbreviations.pdf18.57 kBAdobe PDFView/Open
08_abstract.pdf176.35 kBAdobe PDFView/Open
09_chapter1.pdf1.64 MBAdobe PDFView/Open
10_chapter2.pdf1.2 MBAdobe PDFView/Open
11_chapter3.pdf1.35 MBAdobe PDFView/Open
12_list of publications.pdf23.89 kBAdobe PDFView/Open

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