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Title: Stereoselective total synthesis of biologically active lactones: Synargentolide A, Cryptofolione and Cryptocaryalactone along with the development of novel synthetic methodologies
Researcher: Balasubramanyam, P
Guide(s): Das, Biswanath
Keywords: biologically
Upload Date: 9-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2012
Abstract: The thesis entitled Stereoselective Total Synthesis of Biologically Active Lactones: Synargentolide A, Cryptofolione and newlineCryptocaryalactone along with the Development of Novel Synthetic Methodologies has been divided into three chapters. CHAPTER I: Stereoselective total synthesis of synargentolide A and its epimer newline Natural products containing and#945;, and#946;-unsaturated and#948;-lactone moiety exhibits various pharmacological properties such as cytotoxic, newlineantitumor, antibacterial, ant leukemic and antifungal activities. Synargentolide A 1, a compound of this group was isolated in 1998 by Collett and co-workers from Syncolostemon argentees. The basic structure of and#945;-pyrone 1 is a and#945;,and#946;-unsaturated and#948;-lactone connected to a newlinepolyoxygenated chain. Due to a large range of biological properties this moiety is very attractive to chemists to synthesize. newline
Pagination: 226 p.
Appears in Departments:Department of Chemistry

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File Description SizeFormat 
01_title.pdfAttached File217.58 kBAdobe PDFView/Open
02_dedication.pdf136.06 kBAdobe PDFView/Open
03_certificate.pdf258.76 kBAdobe PDFView/Open
04_acknowledgement.pdf189.29 kBAdobe PDFView/Open
05_abbreviation.pdf185.85 kBAdobe PDFView/Open
06_contents.pdf240.26 kBAdobe PDFView/Open
07_abstract.pdf446.72 kBAdobe PDFView/Open
08_chapter 1.pdf500.17 kBAdobe PDFView/Open
09_chapter 2.pdf554.95 kBAdobe PDFView/Open
10_chapter 3.pdf641.54 kBAdobe PDFView/Open
11_chapter 4.pdf171.68 kBAdobe PDFView/Open
12_references.pdf171.68 kBAdobe PDFView/Open

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