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Title: Different approaches to design and Evaluation of Anti Inflammatory Colon specific Drug Delivery Systems
Researcher: Vemula, Sateesh Kumar
Guide(s): Reddy, V Prabhakar
Keywords: design
Upload Date: 6-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: The intent of current investigation is to make colon targeting newlineflurbiprofen and ketorolac tromethamine matrix and compression coated newlinetablets using time dependent hydroxypropyl methylcellulose, sodium newlinealginate and pH sensitive Eudragit S100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The prepared formulations were optimized using dissolution newlinetests and evaluated for colonic delivery by x-ray imaging and pharmacokinetic studies in healthy humans. The optimized formulation newlineof flurbiprofen and ketorolac tromethamine showed 7.26±0.05 % and 6.75±0.49% (negligible release) in the initial lag period of 5 h followed by progressive release up to 99.27±0.46 % and 97.47±0.93% for 24 h newlinerespectively. The x-ray imaging study in human volunteers illustrated that the tablets arrived to colon with no loss of integrity in the upper gastrointestinal tract. Cmax of colon targeted compression coated tablets newlinewas 10792.62 ng/ml at Tmax 10 h for flurbiprofen and 3562.67 ng/ml at newlineTmax 10 h for ketorolac tromethamine where as in case of immediate release tablets the Cmax was 15684.79 ng/ml at Tmax 3 h for flurbiprofen and 4482.74 ng/ml at Tmax 2 h for ketorolac tromethamine which clearly newlineindicates the capability of compression coated tablets to give colon targeting. Development of compression coated tablets was suitable to target flurbiprofen as well as ketorolac tromethamine to colon.
Pagination: 219 p.
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File84.55 kBAdobe PDFView/Open
02_dedication.pdf81.31 kBAdobe PDFView/Open
03_declaration.pdf127.51 kBAdobe PDFView/Open
04_certificate.pdf97.76 kBAdobe PDFView/Open
05_acknowledgement.pdf190.93 kBAdobe PDFView/Open
06_abstract.pdf72.21 kBAdobe PDFView/Open
07_contents.pdf104.38 kBAdobe PDFView/Open
08_abbreviations.pdf153.14 kBAdobe PDFView/Open
09_list of tables & figures.pdf226.95 kBAdobe PDFView/Open
10_chapter 1.pdf417.25 kBAdobe PDFView/Open
11_chapter 2.pdf1.32 MBAdobe PDFView/Open
12_chapter 3.pdf671.6 kBAdobe PDFView/Open
13_chapter 4.pdf1.12 MBAdobe PDFView/Open
14_chapter 5.pdf701.88 kBAdobe PDFView/Open
15_chapter 6.pdf115.28 kBAdobe PDFView/Open
16_biblography.pdf219.92 kBAdobe PDFView/Open
17_publication.pdf187.81 kBAdobe PDFView/Open

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