Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/18958
Title: Design and Development of Oral Modified release dosage forms of Highly soluble drugs
Researcher: Maram, . Sambasiva Rao
Guide(s): Vidyadhara, S
Raju, N V S
Keywords: Design
Development
Dosage
Drugs
Modified
Upload Date: 6-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: The ultimate goal of the study was to develop a stable, cost effective modified release dosage form of highly soluble drugs such as newlineTrimetazidine dihydrochloride, Glucosamine hydrochloride and Tramadol hydrochloride. It was further aimed to perform the bioavailability and bioequivalence studies for selected model drugs i.e. Trimetazidine dihydrochloride and Glucosamine hydrochloride. Initially the drug-polymer interactions were studied for three model newlinedrugs with excipients by physical bservation, chemical analysis and FTIR studies. The results found that three model drugs were newlinecompatible with excipients present in the study. Trimetazidine dihydrochloride modified release tablets were newlineprepared by direct compression technique by using Xanthan gum and newlinePolyethylene oxide as release modifiers in different concentrations. newlineGlucosamine hydrochloride tablets were prepared by wet newlinegranulation technique by using HPMC K100M and HPMC K200M as a newlinerate controlling polymers in different concentrations. newlineTramadol hydrochloride tablets were prepared by direct newlinecompression technique by using Kollidon SR, Xanthan gum and newlinePolyethylene oxide as controlled release polymers in different newlineconcentrations. newline
Pagination: 206 p.
URI: http://hdl.handle.net/10603/18958
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File73.85 kBAdobe PDFView/Open
02_declaration.pdf59.12 kBAdobe PDFView/Open
03_certificate.pdf59.57 kBAdobe PDFView/Open
04_dedication.pdf53.9 kBAdobe PDFView/Open
05_acknowledgment.pdf72.62 kBAdobe PDFView/Open
06_abstract.pdf53.98 kBAdobe PDFView/Open
07_contents.pdf114.09 kBAdobe PDFView/Open
08_chapter 1.pdf140.48 kBAdobe PDFView/Open
09_chapter 2.pdf93.11 kBAdobe PDFView/Open
10_chapter 3.pdf198.75 kBAdobe PDFView/Open
11_chapter 4.pdf2.99 MBAdobe PDFView/Open
12_chapter 5.pdf5.07 MBAdobe PDFView/Open
13_chapter 6.pdf105.6 kBAdobe PDFView/Open
14_biblography.pdf142.17 kBAdobe PDFView/Open


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