Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/18944
Title: Crystal structures and spectral aspects of mixed ligand transition metal chelates derived from aldehyde based ons donor thiosemicarbazones
Researcher: Jinsa, Jacob Mary
Guide(s): Prathapachandra Kurup, M R
Keywords: Chemistry
Upload Date: 6-Jun-2014
University: Cochin University of Science and Technology
Completed Date: 24/09/2013
Abstract: Thiosemicarbazones have emerged as an important class of ligands over a period of time, for a variety of reasons, such as variable donor properties, structural diversity and biological applications. Interesting as the coordination chemistry may be, the driving force for the study of these ligands has undoubtedly been their biological properties and the majority newlineof the 3000 or so publications on thiosemicarbazones since 2000 have newline alluded to this feature. Thiosemicarbazones with potential donor atoms in their structural skeleton fascinate coordination chemists with their versatile chelating behavior. The thiosemicarbazones of aromatic aldehydes and ketones form stable chelates with transition metal cations by utilizing both their sulfur and azomethine nitrogen as donor atoms. They have been shown to possess a diverse range of biological activities including anticancer, antitumor, antibacterial, antiviral, antimalarial and antifungal properties owing to their ability to diffuse through the semipermeable membrane of the cell lines. The enhanced effect may be attributed to the increased lipophilicity of the metal complexes compared to the ligand newlinealone.
Pagination: 198p.
URI: http://hdl.handle.net/10603/18944
Appears in Departments:Department of Applied Chemistry

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01_title.pdfAttached File145.56 kBAdobe PDFView/Open
02_certificate & declaration.pdf119.94 kBAdobe PDFView/Open
03_preface.pdf146.46 kBAdobe PDFView/Open
04_abbreviations.pdf106.77 kBAdobe PDFView/Open
05_contents.pdf147.67 kBAdobe PDFView/Open
06_chapter 1.pdf304.63 kBAdobe PDFView/Open
07_chapter 2.pdf1.37 MBAdobe PDFView/Open
08_chapter 3.pdf456.23 kBAdobe PDFView/Open
09_chapter 4-5.pdf2.24 MBAdobe PDFView/Open
10_chapter 6.pdf858.41 kBAdobe PDFView/Open
11_chapter 7-8.pdf935.03 kBAdobe PDFView/Open
12_summary.pdf220.56 kBAdobe PDFView/Open
13_cv.pdf5.2 MBAdobe PDFView/Open


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