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Title: Synthesis of Mercapto-(Oxadiazole/Triazole) Carboxylic acid Compounds and their derivatives of Biological interest
Researcher: Rao , Manikrao Anil Madhav
Guide(s): Chaple
Keywords: Biological
Upload Date: 20-May-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2012
Abstract: The research work reported in this dissertation consists of synthesis of newlinepharmacologically active compounds and the modification of their structure according to the result of pharmacological screening. All these synthesized compounds were characterized by satisfactory spectroscopic data. These compounds belongs to the classes of 1,3,4-oxadiazole-2(3H)-thione and 1,2,4- newlinetriazole-3(4H)-thione. All these compounds were screened for different biological newlineactivities including bactericidal, fungicidal, analgesic, anti-inflammatory, newlineanxiolytic and anticonvulsant activities and as expected most of them had exhibited moderate to good activities. Scheme I and Scheme II: Here focus was made mainly on the synthesis of 1,2,4- triazoline-3-thione as the essential pharmacophore and investigation of its combination with various N-substituted carboxamidoalkylthio moiety through sulfur atom and converting them to corresponding sulfoxides and sulfones selectively by solid state green oxidation method using Oxone┬«. newlineAnalgesic and Anti-inflammatory activity: All the synthesized triazole derivatives (11a-k) were found to exhibit potent anti-inflammatory activity but lower analgesic activity as compared to (6a-k). It might be due to increase in distance between aromatic nucleus and side chain nitrogen by one carbon atom as to exhibit analgesic activity, molecule should contain one aromatic nucleus newlineattached to quaternary carbon then ethylene bridge and tertiary nitrogen. N-Phenyl newlinecarboxamidoethylthio-(4H)-1,2,4-triazole (11a) had exhibited equipotent antiinflammatory newlineand analgesic activity as compared to standard drug. Anxiolytic Activity: All the compounds (6a-k and 11a-k) were tested for their Anxiolytic activity. There was increase in percent time spent and number of entries newlinein the open arm but the Anxiolytic activity was found to be very less as compared newlineto diazepam.
Pagination: P. 249
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File156.72 kBAdobe PDFView/Open
02_dedication.pdf46.19 kBAdobe PDFView/Open
03_certificate.pdf129.61 kBAdobe PDFView/Open
04_declaration.pdf106.71 kBAdobe PDFView/Open
05_acknowledgment.pdf92.02 kBAdobe PDFView/Open
06_abbreviations.pdf45.14 kBAdobe PDFView/Open
07_abstract.pdf76.27 kBAdobe PDFView/Open
08_contents.pdf59.7 kBAdobe PDFView/Open
09_list of figures & tables.pdf86.16 kBAdobe PDFView/Open
10_chapter 1.pdf188.02 kBAdobe PDFView/Open
11_chapter 2.pdf290.45 kBAdobe PDFView/Open
12_chapter 3.pdf112.73 kBAdobe PDFView/Open
13_chapter 4.pdf274.36 kBAdobe PDFView/Open
14_chapter 5.pdf298.62 kBAdobe PDFView/Open
15_chapter 6.pdf544.24 kBAdobe PDFView/Open
16_chapter 7.pdf329.34 kBAdobe PDFView/Open
17_chapter 8.pdf2.96 MBAdobe PDFView/Open
18_chapter 9.pdf143.74 kBAdobe PDFView/Open

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