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Title: Amphiphiles Design Syntheses Studies on Their Biomolecular Interactions and Micellar Catalysis
Researcher: Kumar, Vikash
Guide(s): Banerjee, Mainak
Keywords: Pharmacy, Amphiphiles, Biomolecular Interactions, Micellar Catalysis
University: Birla Institute of Technology and Science
Completed Date: 2017
Abstract: Title of the thesis: Tailor-Made Synthesis of Amphiphilic Molecules: Studies on their newlineMorphoogical Features and Potential Applications newlineAmphiphiles having built-in hydrophilic and lipophilic properties and they can be classified in to different types e.g. conventional surfactants, gemini amphiphiles, bolaamaphiphiles etc. newlineThere are 7 chapters in this thesis, which are as follows. newlineChapter I: Introduction newlineThis chapter provides a general introduction on amphiphiles with an emphasis on their newlinesynthesis and applications. newlineChapter II: Synthesis, surface properties, DNA binding and cytotoxicity of D-Glucose based gemini surfactants newlineThis chapter describes synthesis of four new D-glucose derived m-s-m type quaternary newlineammonium gemini surfactants with variable spacer and tail length by a simple and efficient methodology utilizing the free C-3 hydroxy group of diisopropylidene glucose. Apart from showing good surface properties, these gemini surfactants showed low cytotoxicity by MTT assay on HeLa cell line. The DNA binding capabilities of these surfactants were determined by agarose gel electrophoresis, fluorescence titration, and DLS experiments. The preliminary studies by agarose gel electrophoresis indicated chain length dependent DNA binding model structure of gemini amphiphiles self assembled gemini amphiphile pDNA ethidium bromide complex newline1,2:5,6-Di-O-isopropyledene glucofuranoside newlineGemini pDNA Complex ethidium bromide newlineFig. A. Graphical abstract for the synthesis of gemini surfactants and its applications newlineabilities, further supported by ethidium bromide exclusion experiments. Two of the D-glucose derived gemini surfsurfactants showed effective binding with pET-28a plasmid DNA at relatively low N/P ratio. newlineChapter III: Synthesis and catalytic application of a novel class of D-glucose basedbolaamphiphiles newlineThis chapter describes synthesis of three sugar based bolaamphiphiles from D-glucose. The resulting bolaamphiphiles showed unique aggregation behavior in aqueous solution. These sugar-based anionic bolaforms formed vesicl
Pagination: 197p.
Appears in Departments:Pharmacy

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