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Title: Biochemical markers of synovium, cartilage and bone in rheumatoid arthritis
Researcher: Vinod A N
Guide(s): Nalini Ganesan
Keywords: Arthritis
Bone In Rheumatoid
Upload Date: 24-Apr-2014
University: Sri Ramachandra University
Completed Date: 2013
Abstract: Rheumatic diseases were first recognized by Hippocrates in the fourth century B.C. The term and#8213;rheumaand#8214; indicates continuous flow of pain through the different joints of the body. Goemaere et al1 reported the appearance and distribution of lesions in ancient skeletons suggesting that rheumatoid arthritis may have existed in North America at least 3000 years ago. The first clinical description of rheumatoid arthritis is credited to Augustin-Jacob Landre Beauvais (1800) in his thesis.2 Introduction Rheumatoid arthritis (RA) is a chronic, inflammatory systemic disease of unknown etiopathogenesis. It is one of the commonest autoimmune diseases.3 The major characteristic feature is the chronic, erosive synovitis of peripheral joints due to the uncontrolled proliferation of synovial tissue which leads to severe joint destruction.2 In addition to early disability and premature mortality, symmetric swelling of peripheral joints is the hallmark of the disease.4 Symptoms of Rheumatoid arthritis The symptoms of rheumatoid arthritis mainly involving the joints; typically affected are those of the hands, wrists, knees and feet. The synovial joint inflammation which leads to cartilage destruction, bone erosions and joint deformities is the important aspect of rheumatoid arthritis. The characteristic feature of the disease is experiencing pain, warmth, swelling, tenderness, stiffness and limitation of motion.5,6 Extra-articular involvement is another feature of RA and this can range from rheumatoid nodules occurring most commonly over bony prominences to life-threatening heart nodules and vasculitis.7 The course of rheumatoid arthritis can be quite variable, and can differ in different patients. Some RA patients may experience only a mild illness for brief duration involving one or two joints with minimal joint damage, whereas others may have a relentless progressive polyarthritis with noticeable functional impairment and disability.2 Rheumatoid arthritis is also associated with symptoms of fatigue, pain, and sleep
Pagination: 246p.
Appears in Departments:Medical College

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10_discussion.pdfAttached File1.18 MBAdobe PDFView/Open
11_summary and conclusion.pdf219.13 kBAdobe PDFView/Open
12_future research.pdf170.74 kBAdobe PDFView/Open
13_references.pdf1.66 MBAdobe PDFView/Open
14_publications and presentations.pdf138.62 kBAdobe PDFView/Open
01_title.pdf65.19 kBAdobe PDFView/Open
02_certificate.pdf83.27 kBAdobe PDFView/Open
03_declaration.pdf81.91 kBAdobe PDFView/Open
04_acknowledgement.pdf99.34 kBAdobe PDFView/Open
05_abbreviations.pdf59.81 kBAdobe PDFView/Open
06_contents.pdf24.38 kBAdobe PDFView/Open
07_chapter 1.pdf491.26 kBAdobe PDFView/Open
08_chapter 2.pdf297.76 kBAdobe PDFView/Open
09_results.pdf1.49 MBAdobe PDFView/Open

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