Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/17902
Title: An investigation into the relationship of insulin and other related biochemical parameters with coronary artery disease in a south indian population
Researcher: Kannan G
Guide(s): Rajendran N N
Keywords: Biochemical Parameters
Coronary Artery Disease
Insulin
South Indian Population
Upload Date: 24-Apr-2014
University: Sri Ramachandra University
Completed Date: 2012
Abstract: Coronary artery disease (CAD) is the leading cause of death worldwide. It has reached enormous proportions striking more and more at younger subjects and has transformed as the greatest epidemic that mankind has ever-faced. Moreover, people hailing from Indian subcontinent have a higher probability of dying due to CAD. In the past three decades, CAD rates have doubled in rural areas and tripled in urban areas of India (Chopra and Wasir, 1998; WHO, 2009). This alarming trend has to be reversed by intense research into its cause and prevention. CAD occurs when the arteries that supply blood to the heart muscle, harden and narrow (Bhati, 2011; Heart diseases, 2011). This results in the loss of oxygen and nutrients to myocardial tissue because of diminished coronary blood flow. The reduction in blood flow can lead to acute coronary syndrome. Atherosclerosis is the usual cause of CAD. In this condition (Figure 1), fatty, fibrous plaques (Figure 2), including calcium deposits, narrow the lumen of the coronary arteries; thereby reducing the volume of blood flowing through them, and leading to myocardial ischemia. Plaque formation (Figure 3) also predisposes to thrombosis, which can provoke myocardial infarction (MI) (Lippincott and Wilkins, 2005). Atherosclerosis usually develops in high-pressure arteries, such as those in the heart, brain, kidneys, and in the aorta, especially at bifurcation points.
Pagination: 286p.
URI: http://hdl.handle.net/10603/17902
Appears in Departments:College of Pharmacy

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11_chapter 4.pdf1.32 MBAdobe PDFView/Open
12_chapter 5.pdf825.7 kBAdobe PDFView/Open
13_chapter 6.pdf1.75 MBAdobe PDFView/Open
14_chapter 7.pdf403.07 kBAdobe PDFView/Open
15_chapter 8.pdf189.66 kBAdobe PDFView/Open
16_appendices.pdf4.32 MBAdobe PDFView/Open
01_title.pdf150.09 kBAdobe PDFView/Open
02_certificate.pdf99.83 kBAdobe PDFView/Open
03_declaration.pdf61.63 kBAdobe PDFView/Open
04_acknowledgements.pdf67.09 kBAdobe PDFView/Open
05_contents.pdf101.54 kBAdobe PDFView/Open
06_list of tables.pdf104.19 kBAdobe PDFView/Open
07_list of figures.pdf177.99 kBAdobe PDFView/Open
08_chapter 1.pdf783.86 kBAdobe PDFView/Open
09_chapter 2.pdf686.5 kBAdobe PDFView/Open


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