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Title: Synthesis of novel biologically active organic compounds
Researcher: Sreenivasulu M
Guide(s): Chandra Sekhar K B
Keywords: Organic compounds
N-heterocyclic carbenes
Upload Date: 17-Apr-2014
University: Jawaharlal Nehru Technological University, Anantapuram
Completed Date: 24/12/2012
Abstract: The thesis entitled SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS is divided into five chapters. Chapter 1 deals with general survey of literature on and#945;-hydroxy esters, o-acyl mandelic esters and review on importance of N-heterocyclic carbenes in organic chemistry. The chapters 2, 3, and 4 deal with the general survey of literature on the importance of N-heterocyclic carbenes in reduction, hydroacylation and coupling reactions and their use in synthesis of a novel aromatic compounds and experimental procedure for our synthesis of those novel aromatic compounds. Chapter 5 deals with summary and conclusion. Chapter-I: Introduction on N-heterocyclic carbenes In this chapter presents an overview of literature survey on and#945;-hydroxy esters, o-acyl mandelic esters. Also presents review on N-heterocyclic carbenes and its applications in organic chemistry or synthesis of active intermediates. Chapter-II: Synthesis of novel and#945;-hydroxy esters, o-acyl mandelic esters by reduction/hydroacylation of activated ketones with aldedhydes mediated by 1, 3-Bis(2,4,6-trimethylphenyl)imidazolium chloride: In this chapter, we have reported novel and#945;-hydroxy esters and o-acyl mandelic esters by reduction/hydroacylation of and#945;-ketoesters with aldehydes by of 1,3-bis(2,4,6-trimethyl phenyl)imidazolium chloride and triethylamine at ambient temperature via generating N-heterocyclic carbene insitu. An improved catalytic system for hydroacylation/reduction of activated ketones NHC -mediated reduction of and#945;-keto esters in protic solvent Screening of NHC ligands (A-D) with different Bases: xiii The reaction of benzaldehyde 1a with methyl 2-(2-chlorophenyl)-2-oxoacetate 2a in the presence of salts A D (Figure 1) using various bases in methanol (Scheme1). As expected, the carbonyl reduction product 4a was isolated. Among all the salts screened, the use of sterically encumbered 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride A was found to be the most effective in terms of product yield.
Pagination: xxxvii, 237p.
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File12.91 kBAdobe PDFView/Open
02_certificate.pdf47.37 kBAdobe PDFView/Open
03_acknowlegements.pdf64.6 kBAdobe PDFView/Open
04_contents.pdf150.44 kBAdobe PDFView/Open
05_preface.pdf547.05 kBAdobe PDFView/Open
06_list of tables and figures.pdf168.97 kBAdobe PDFView/Open
07_chapter 1.pdf1.37 MBAdobe PDFView/Open
08_chapter 2.pdf2.18 MBAdobe PDFView/Open
09_chapter 3.pdf1.44 MBAdobe PDFView/Open
10_chapter 4.pdf2.73 MBAdobe PDFView/Open
11_chapter 5.pdf272.66 kBAdobe PDFView/Open
12-references.pdf134.28 kBAdobe PDFView/Open
13_publication 1.pdf1.8 MBAdobe PDFView/Open
14_publication 2.pdf305.69 kBAdobe PDFView/Open

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