Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/17778
Title: Studies on cell surface antigens of a rat histiocytic cell line : Molecular cloning and characterization of a tumor specific antigen
Researcher: Krishna, T Murali
Guide(s): Khar, K Ashok
Keywords: Molecular Biology
cell surface antigens
histiocytic cell line,
cloning
tumor specific antigen
Upload Date: 16-Apr-2014
University: Jawaharlal Nehru University
Completed Date: 1996
Abstract: As a result of transformation, a normal cell undergoes changes in a restricted set of cellular newlinegenes. During the course of this development, the properties of a maiignant cell are altered newlineconsiderably and changes such as anchorage independence, loss of contact inhibition, newlineincreased uptake of essential nutrients, low serum requirements in culture, invasiveness and newlineability to metastasize are frequently observed. As a result of accumulating mutations, the newlineprotein profile of a malignant cell is altered considerably with respect to its normal tissue newlinecounterpart. Some of these altered proteins or neoantigens are capable of evoking an immune newlineresponse against the tumor in the host and these are known as tumor specific antigens. newlineA large amount of data regarding the biochemical and immunological characterization of newlinetumor specific antigens has been generated as a result of analysis of protein preparations from newlinevarious tumors. Tumor specific antigens are primarily defined by their ability to evoke an newlineimmune response in a syngeneic host. The ability of a tumor antigen to evoke an immune newlineresponse in the host varies depending upon the tissue of origin and the initial carcinogenic newlineevent. Based on the causal agent, type of cell and the molecular characterization of the newline newlineantigen expressed tumor antigens have been classified as being unique to i) a tumor, ii) to newlinea class of tumor, iii) to the transforming agent, and iv) common to many types of tumors. newlineNumerous examples of these various classes have been identified and characterized from newlinedifferent tumors and the immune responses evoked by these antigens also vary considerably newlineranging from the weakly immunogenic tumor antigens of spontaneous tumors to the highly newlineimmunogenic viral antigens. newlineThe type of immune responses evoked by these various classes of antigens ranges from newlinehumoral to cellular or both. In the recent past, CDS+ T cell responses have been shown to newlineplay a major role in the rejection of tumors.
Pagination: 93p.
URI: http://hdl.handle.net/10603/17778
Appears in Departments:Centre for Cellular and Molecular Biology

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01_title.pdfAttached File27.21 kBAdobe PDFView/Open
02_certificate.pdf24.62 kBAdobe PDFView/Open
03_acknowledgements.pdf79.13 kBAdobe PDFView/Open
03_contents.pdf114.11 kBAdobe PDFView/Open
04_list of abbriviations.pdf44.56 kBAdobe PDFView/Open
05_abstract.pdf198.92 kBAdobe PDFView/Open
06_chapter 1.pdf899.85 kBAdobe PDFView/Open
07_chapter 2.pdf1.51 MBAdobe PDFView/Open
08_chapter 3.pdf8.99 MBAdobe PDFView/Open
09_chapter 4.pdf803.84 kBAdobe PDFView/Open
10_references.pdf672.97 kBAdobe PDFView/Open


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