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Title: Hypolipidemic and cardioprotective effect of cymbopogon citratus DC stapf
Researcher: Gayathri, K
Guide(s): Hannah Rachel Vasanthi A
Victor, Rajamanickam G
Keywords: Cardioprotective effect
Folklore medicine
Lemon grass
Prevention of heart diseses
Upload Date: 1-Apr-2014
University: SASTRA University
Completed Date: n.d.
Abstract: Cymbopogon citratus (C.citratus), commonly known as lemon grass belongs to the family Poaceae. It is used in many South East Asian cultures as a flavoring agent and in folklore medicine. In the present research work, C.citratus collected in pre and post newlinemonsoon periods, are subjected to various physicochemical analyses to know the quality newlineof the collected samples. The results of physicochemical analysis reveal that the quality of post monsoon plant sample is quite good and appropriate for further study. Moreover, the primary, secondary metabolites and micronutrients are present in substantial amount in the plant material to be considered as a nutritional supplement. As a part of standardisation, various extracting procedures are employed. Preliminary phytochemical analysis of all the extracts are carried out and it was found that 75% Hydroalcoholic Extract (HAE) has better yield of phytochemicals. Characterisation of C.citratus HAE and its oil is carried out using High Performance Thin Layer Chromatography (HPTLC) and Gas Chromatography-Mass Spectrometry (GC-MS) and a number of phytoconstituents such as citral, and#946;-myrcene, geraniol were identified. Comparative free radical scavenging activity of HAE and oil of C.citratus is carried out using various invitro assays and it was found that HAE has potent free radical scavenging property. Hypolipidemic activity of both HAE and oil is compared in Triton WR 1339 induced hyperlipidemic rat model. The results of hypolipidemic activity have also mimicked as that of the invitro free radical scavenging activity. Hence, HAE is used to evaluate the cardioprotective activity in isoproterenol (ISO) induced cardiotoxicity model. The various risk factors of ischemic heart disease such as lipids and oxidative stress have been extensively studied by the intervention of HAE for a period of 58 days, followed by induction of ischemia in male Wistar rats. The results obtained reflected that, HAE has exhibited dose dependant cardioprotective activity; as evidenced by its hypolipidemi
Pagination: xxi, 182p.
Appears in Departments:School of Chemical and Biotechnology

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02_certificate.pdf52.14 kBAdobe PDFView/Open
03_dedication.pdf7.69 kBAdobe PDFView/Open
04_declaration.pdf50.8 kBAdobe PDFView/Open
05_content.pdf74.28 kBAdobe PDFView/Open
06_acknowledgemnt.pdf56.93 kBAdobe PDFView/Open
07_abstract.pdf69.31 kBAdobe PDFView/Open
08_list_of_tables.pdf57.12 kBAdobe PDFView/Open
09_appendix.pdf67.82 kBAdobe PDFView/Open
10_chapter_01.pdf495.98 kBAdobe PDFView/Open
11_chapter_02.pdf243.34 kBAdobe PDFView/Open
12_chapter_03.pdf274.47 kBAdobe PDFView/Open
13_chapter_04.pdf535.21 kBAdobe PDFView/Open
14_biblography.pdf191.05 kBAdobe PDFView/Open

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