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Title: Pharmacognostical phytochemical and pharmacological evaluation of salvadora persica for the treatment of lithiasis
Researcher: Geetha, K
Guide(s): Manavalan, R
Venkappayya, D
Keywords: Kidney stone treatment
Salvadora persica
Upload Date: 18-Mar-2014
University: SASTRA University
Completed Date: n.d.
Abstract: Lithiasis (kidney stone) is a common recurrent worldwide problem. Salvadora newlinepersica which belongs to the family Salvadoraceae, a plant commonly used as folklore newlinemedicine for Lithiasis in the southern parts of India. Relevant scientifically proven data newlinesupporting this claim were lacking and hence a detailed study using the leaves of this newlineplant was planned. Pharmacognostic studies of leaves of Salvadora persica have brought newlineto light microscopic features as well as preliminary phytochemical data of diagnostic newlinevalues. The alcoholic (95%) and aqueous extracts of leaf powder of S.persica were newlineevaluated for its inhibitory potential on Lithiasis (stone formation) induced by oral newlineadministration of 0.75% ethylene glycolated water to adult male albino wistar rats for 28 newlinedays. Alterations were observed in urinary concentration of crucial ions viz calcium, newlineoxalate and phosphate, serum urea, creatinine, uric acid, lipid peroxidation, activities of newlinetissue enzymic (superoxide dismutase, glutathione peroxidase) and non-enzymic newline(glutathione, vitamin C and vitamin E) antioxidants, along with an increased activity of newlineoxalate metabolizing enzymes GAO and LDH in hyperoxaluric group. These abnormal newlinebiochemical aberrations were attenuated with treatment of alcoholic and aqueous extracts newlineof S.persica in curative and preventive regimens (CR and PR). Histopathological findings newlinealso showed signs of improvement after treatment with the extracts both in the curative newlineand preventive regimens. Evaluation of biochemical parameters indicated that alcoholic newlineextract show evidence of more antilithiatic activity than aqueous extract. Consequently, newlinethe compounds present in the alcoholic extract of leaves of S.persica were isolated. newlineTriterpenes betulin and and#946;-amyrin were isolated from the alcoholic extract and newlinecharacterized by UV, IR, NMR and Mass spectroscopical studies. newlineAs very less quantity of betulin (0.0018%) was present in the leaf powder, and#946;- newlineamyrin (0.040%) was screened for antilithiatic activity using ethylene glycol induced newlinehyperoxaluria model.
Pagination: xiii, 135p
Appears in Departments:School of Chemical and Biotechnology

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02_certificate.pdf85.24 kBAdobe PDFView/Open
03_declaration.pdf69.4 kBAdobe PDFView/Open
04_acknowledgement.pdf71.32 kBAdobe PDFView/Open
05_table_of_contents.pdf125.67 kBAdobe PDFView/Open
06_abbreviations.pdf74.28 kBAdobe PDFView/Open
07_abstract.pdf84.34 kBAdobe PDFView/Open
08_chapter_01.pdf808.34 kBAdobe PDFView/Open
09_chapter_02.pdf128.73 kBAdobe PDFView/Open
10_chapter_03.pdf88.63 kBAdobe PDFView/Open
11_chapter_04.pdf231.37 kBAdobe PDFView/Open
12_chapter_05.pdf1.9 MBAdobe PDFView/Open
13_chapter_06.pdf96.22 kBAdobe PDFView/Open
14_bibliography.pdf140.81 kBAdobe PDFView/Open
15_appendix_01.pdf83.7 kBAdobe PDFView/Open
16_appendix_02.pdf2.94 MBAdobe PDFView/Open

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