Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/17068
Title: Evaluation of treatment pattern and outcome with emphasis on pralidoxime dosage regimen in organophosphorus poisoning
Researcher: Thunga, Girish
Guide(s): Vidyasagar, Sudha
Keywords: Medicine
Kinetics
Pralidoxime
Methyl Parathion
Continuous Infusion
Organophosphate Poisoning
Upload Date: 7-Mar-2014
University: Manipal University
Completed Date: 21/01/2014
Abstract: Organophosphate (OP) poisoning is one of the major causes among many other accidental or intentional poisoning reported from developing countries like India. Methyl parathion is the one of the commonly available OP compound responsible for high mortality rate. Atropine is the widely used antidote for symptomatic management of OP poisoning. Pralidoxime (PAM) has been indicated as a specific antidote for OP poisoning; however regarding the dosage regimen used for OP poisoning management has been controversial. The present study aimed to identify the appropriate dosage regimen of PAM, its ideal serum levels for the management of OP poisoning. Furthermore, we also evaluated the influence of PAM serum level with the methyl parathion level in the patients. A prospective, observational study was carried in a total of 256 OP poisoning patients reported to emergency ward of a tertiary care teaching hospital admitted during 2009 to 2013. The patient s demographical, clinical characteristics and severity were assessed at admission. Patients were categorized into 4 different groups viz. patient s without PAM , intermittent dosing, 500mg/ hour, 1g/ hour group, based on the PAM dosage regimens received,. Outcomes like hospitalization days, ventilatory days, doses of atropine required and incidence of intermediate syndrome and the clinical evaluation were compared with the PAM regimens prescribed. Blood levels of PAM were estimated in patients by HPLC method to correlate benefits versus risks. Blood levels of methyl parathion also estimated by HPLC method and compared with that of the levels of PAM and its outcomes. The results showed that majority of OP poisoned patients were in the age group of 21- 30 years, and males predominated over females. Clinical Severity assessment of higher proportion of patients was moderate to high severity. Outcome analysis showed patients of continuous infusion of pralidoxime had significantly improved recovery rate with least sequel and fatality rate (plt0.01).
Pagination: --
URI: http://hdl.handle.net/10603/17068
Appears in Departments:Dept. of Medicine

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01_title.pdf.pdfAttached File78.85 kBAdobe PDFView/Open
02_certificate.pdf605.06 kBAdobe PDFView/Open
03_abstract.pdf.pdf123.2 kBAdobe PDFView/Open
04_ declaration.pdf.pdf231.55 kBAdobe PDFView/Open
05_ackowlegement.pdf.pdf82.19 kBAdobe PDFView/Open
06_content.pdf.pdf120 kBAdobe PDFView/Open
07_list of tables.pdf.pdf107.75 kBAdobe PDFView/Open
08_list of figure.pdf.pdf89.15 kBAdobe PDFView/Open
09_abbrivation.pdf.pdf86 kBAdobe PDFView/Open
10_chapter 1.pdf654.95 kBAdobe PDFView/Open
11_chapter 2.pdf778.99 kBAdobe PDFView/Open
12_chapter 3.pdf807.41 kBAdobe PDFView/Open
13_chapter 4.pdf723.19 kBAdobe PDFView/Open
14_chapter 5.pdf742.27 kBAdobe PDFView/Open
15_conclusion.pdf240.84 kBAdobe PDFView/Open
16_summary.pdf256.81 kBAdobe PDFView/Open


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