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Title: Neuroprotective effect of bacosides and curcuminoids in aged rats - implications for senile dementia of Alzheimers type (SDAT)
Researcher: Rastogi, Manisha
Guide(s): Dubey, G B
Parimala Devi B
Keywords: Ageing
Oxidative stress
Upload Date: 26-Feb-2014
University: SASTRA University
Completed Date: n.d.
Abstract: Ageing is characterized by the declined ability to respond to stress, reduced cellular functions and increased incidence of age related pathologies, like Senile Dementia of Alzheimer s Type (SDAT). The treatment of SDAT still remains a challenge, however converging evidences suggested that age associated neurodegeneration can actually be prevented by neuroprotective strategies. In this regard, the disease preventive and health promotive approach of and#8213;Ayurvedaand#8214; which involve the use of plant extracts alone or in combination may provide promising therapeutic benefits by promoting the healthy brain ageing, and preventing or delaying the susceptibility to develop SDAT. Although, the textual and experience based evidences regarding the efficacy of medicinal plants are abundant, limited experimental studies are available inorder to understand and validate their neuroprotective mechanism of action. In the present research work, bacosides (saponins) and curcuminoids (polyphenols) of Bacopa monnieri (L.) whole plant and Curcuma longa (L.) rhizomes respectively were investigated for their neuroprotective mechanism of action to promote and#8213;successful ageingand#8214; and prevent or delay the progression of SDAT in the aged Wistar rats. Bacosides and curcuminoids were extracted from the standard extract of Bacopa monnieri whole plant and Curcuma longa rhizomes respectively and quantified for their marker components by HPLC. The isolated bacosides and curcuminoids fractions were evaluated for their potential total antioxidant capacity, total NO scavenging and acetylcholinesterase inhibition activities in in-vitro assays and compared with respective standard. Bacosides and curcuminoids were subjected to in vivo studies where initially the optimum dose of both the putative drug candidates were determined by administering the drugs orally to aged Wistar rats for three months in dose dependant manner. The optimum dose of 200mg/kg and 100 mg/kg for bacosides and curcuminoids respectively were selected and was used for further experimentation
Pagination: x,208p.
Appears in Departments:School of Chemical and Biotechnology

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01_title.pdfAttached File114.71 kBAdobe PDFView/Open
02_dedication.pdf129.21 kBAdobe PDFView/Open
03_acknowledgements.pdf206.35 kBAdobe PDFView/Open
04_certificate & declarations.pdf172.89 kBAdobe PDFView/Open
05_contents.pdf217.86 kBAdobe PDFView/Open
06_list of tables & figures.pdf220.43 kBAdobe PDFView/Open
07_abbreviations.pdf201.88 kBAdobe PDFView/Open
08_abstract.pdf255.29 kBAdobe PDFView/Open
09_chapter 1.pdf223.4 kBAdobe PDFView/Open
10_chapter 2.pdf202.62 kBAdobe PDFView/Open
11_chapter 3.pdf201.87 kBAdobe PDFView/Open
12_chapter 4.pdf970 kBAdobe PDFView/Open
13_chapter 5.pdf357.93 kBAdobe PDFView/Open
14_chapter 6.pdf1.49 MBAdobe PDFView/Open
15_chapter 7.pdf290.02 kBAdobe PDFView/Open
16_chapter 8.pdf218.71 kBAdobe PDFView/Open
17_references.pdf632.18 kBAdobe PDFView/Open
18_bibliography.pdf337.92 kBAdobe PDFView/Open

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