Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/16119
Title: Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential
Researcher: Chemansaheb Meerasaheb Jamkhandi
Guide(s): John Intru Disouza
Keywords: Pharmaceutical Sciences
Upload Date: 21-Feb-2014
University: Shri Jagdishprasad Jhabarmal Tibarewala University
Completed Date: 10-09-2013
Abstract: The objective of the present study was to evaluate antioxidant, antibacterial activity of a series of Benzotriazole Substituted with N-Phenylacetamide (Ia to Va), acetylcarbamic acid (Ib to Vb) derivatives. The derivatives were synthesized with planned synthetic pathway were characterized and evaluated for antimicrobial activity which was measured against norfloxacin and ketoconazole as standards drugs. It was found that the derivatives from 1a to Va and Ib to Vb were shown to produce good antimicrobial activity against, S aureus, S typhi, B subtilis, E coli, C albicans, A niger. The all the derivatives show satisfactory anti-microbial activities. The antioxidant activity was measured by adopting Griess reaction assay method. Sodium nitroprusside was used to produce nitric oxide which oxidizes sulphonilamide present in Griess reagent to form diazonium salt and on further reacts with N-(naphthalene-1-yl)ethylenediamine (NED) to form chromophore. The nitrogen scavenging activity of the derivatives was measured by absorption of chromophore formed with spectrophotometer at 548nm using ascorbic acid as standard. IIa, IIIa and IIb derivatives showed highest antioxidant activity and rest of the derivatives were having medium activity. The data obtained was expressed statistically. newlineKey Words: Antibacterial, Antifungal, Antioxidants, Scavenging activity, Benzotriazole derivatives, Griess reagent. newline newline
Pagination: 
URI: http://hdl.handle.net/10603/16119
Appears in Departments:Faculty of Pharmacy



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