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Title: Polymorphic regions in the interleukin 1 fc gamma receptors tnfa genes and susceptibility to chronic periodontitis a genetic association study
Researcher: Vamsi lavu
Guide(s): Suresh rao
Keywords: Aassociation study.
Chronic periodontitis
Factor alpha
Fc Gamma receptor
Gene polymorphism
Tumor necrosis
University: Sri Ramachandra University
Completed Date: 12/07/2017
Abstract: The present study evaluated the association between the SNP s in IL1 A (-889, +4845), IL1B 511 3954 and FCGR2A H131R FCGR2B Ile 232Thre TNFA 1031 863 and periodontitis susceptibility in a hospital based cohort from South India. In addition a co-relation of the gingival crevicular fluid levels of Interleukin beta and Tumor necrosis factor alpha with the SNP genotype IL1B 511 3954 TNFA 1031 863 was also performed to assess the functionality of the SNP. Linkage disequilibrium analysis and Mult factorial dimensionality reduction analysis was also performed to identify the presence of any interaction between SNP of the genes evaluated A combination of Sanger sequencing and Real time SNP genotyping methods was used to identify the genotypes and cytometric bead array for the protein assessment in gingival crevicular fluid. A significantly higher distribution of the variant alleles in IL1B 3954 IL1RN FCGR2A H131R was observed amongst subjects with chronic periodontitis. An increase in risk ranging from 175 19 was observed when the subjects carried the variant alleles of the IL1B 3954 IL1RN, FCGR2A H131R newline
Pagination: 1-255
Appears in Departments:Dental College

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01 title.pdfAttached File43.16 kBAdobe PDFView/Open
02 certificate.pdf367.83 kBAdobe PDFView/Open
03 contents.pdf66.76 kBAdobe PDFView/Open
04 lits of tables.pdf146.83 kBAdobe PDFView/Open
05 lits of figures.pdf138.87 kBAdobe PDFView/Open
06 acknowledgements.pdf13.51 kBAdobe PDFView/Open
07 chapter _1.pdf678.97 kBAdobe PDFView/Open
08 chapter _2.pdf1.07 MBAdobe PDFView/Open
09 chapter _3.pdf1.26 MBAdobe PDFView/Open
10 chapter _4.pdf1.3 MBAdobe PDFView/Open
11 chapter _5.pdf312.01 kBAdobe PDFView/Open
12 chapter _6.pdf1.77 MBAdobe PDFView/Open
13 chapter _7.pdf382.58 kBAdobe PDFView/Open
14 chapter _8.pdf315.84 kBAdobe PDFView/Open
15 appendix.pdf1.78 MBAdobe PDFView/Open
17 publications.pdf137.59 kBAdobe PDFView/Open

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