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Title: Studies on antioxidants and antimetastatic components from spices against cancer
Researcher: Harish Nayaka, M A
Guide(s): Dharmesh, Shylaja M
Keywords: Biochemistry
Upload Date: 14-Feb-2014
University: University of Mysore
Completed Date: December 2007
Abstract: Thesis Title: Studies on Antioxidants and Antimetastatic Components from Spices Against Cancer Cancer is a complex multi-step disease, rising constantly in both developing and developed countries leading to mortality. Developing a strategy for cancer therapy has been difficult since cancer cell poses lots of challenges to normal cells by self-regulating their survival and dysregulating normal cellular action. Antioxidants, quenchers of free radicals - that initiates cancer, chemo/radio therapeutics, that inhibit proliferative cancer cell, surgery/immuno therapies that envisage the removal of the affected tissue/cell, have been in practice for cancer therapy; yet cancer cells find their way successful due the limitations encountered in these therapies such as lack of discrimination between cancer cell and a normal cell. Current thesis entitled Studies on Antioxidants and Antimetastatic Components from Spices Against Cancer explores the possibility of dietary antioxidants and antimetastatic polysaccharides that can effectively bring down oxidative stress and target galectin-3, a key molecule in metastasis causing severity of cancer pathogenicity and death as revealed in scheme - 1. During the study, potential water soluble antioxidants and antimetastatic polysaccharides from Black cumin BC - Nigella Sativa and Swallow root SR- Decalepis hamiltonii have been identified, characterized and determined their efficacy in vitro and in vivo. Results indicated tannic acid and gentisic acid followed by gallic, protocatechuic, and vanillic acid as major multi-potent antioxidants in BC and SR respectively. SR also found to contain higher levels of 2-Hydroxy-4-methoxybenzaldehyde (HMBA) but contributing little to the activity. A potent galectin-3 inhibitory pectic polysaccharide was also identified in SR - SRPP and structure function analysis reveal the presence of higher levels of galactose
Pagination: 210p.
Appears in Departments:Department of Biochemistry

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01_title.pdfAttached File101.84 kBAdobe PDFView/Open
02_declaration.pdf64.01 kBAdobe PDFView/Open
03_certificate.pdf64.45 kBAdobe PDFView/Open
04_acknowledgements.pdf118.89 kBAdobe PDFView/Open
05_contents.pdf96.95 kBAdobe PDFView/Open
06_abbreviation.pdf118.69 kBAdobe PDFView/Open
07_abstract.pdf122.18 kBAdobe PDFView/Open
08_synopsis.pdf169.49 kBAdobe PDFView/Open
09_chapter 1.pdf1.33 MBAdobe PDFView/Open
10_chapter 2.pdf1.89 MBAdobe PDFView/Open
11_chapter 3.pdf989.92 kBAdobe PDFView/Open
12_chapter 4.pdf1.47 MBAdobe PDFView/Open
13_chapter 5.pdf1.53 MBAdobe PDFView/Open
14_references.pdf259.24 kBAdobe PDFView/Open
15_publication.pdf109.58 kBAdobe PDFView/Open

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