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Title: Biocomposites containing collagen D amino acids and phytosome nanoparticles as drug carriers and tissue engineering scaffolds
Researcher: Krishnamoorthy G
Guide(s): Mandal A B
Keywords: Biocomposites, Collagen D amino acids, phytosome, nanoparticles, drug carriers, tissue engineering, scaffolds
Upload Date: 30-Jan-2014
University: Anna University
Completed Date: 
Abstract: The 21st century has embraced the appearance of green chemistry and nanomedicine era that have attracted the attention and participation of many researchers in synthesis and modification of novel pharmaceutical chemicals and polymers and biopolymers, and also stabilization of biomaterials. The use of collagen as a biomaterial is currently undergoing a renaissance in the drug delivery system and tissue engineering fields. Collagen is subjected to additional processing to fabricate various forms of biomaterials into useful devices and can be formulated into matrices such as membranes, films, porous gels, filaments, tubes, etc. Hence, the present work aims at providing improved properties of a collagen based material, which overcomes the above problems of existing biomaterials. This thesis focuses on green chemistry approach to improve the stability of collagen scaffolds by crosslinking them with D-AAs and incorporation of phytosome nanoparticles (PNs) for their possible use in drug delivery and tissue engineering. In this study, D-AAs assisted, 1-ethyl-3-(3-dimethylaminopropyl)- carbodiimide (EDC)/N-hydroxyl succinimide (NHS) initiated crosslinking of collagen matrix (Coll-D-AAs) were prepared and characterized. Fourier transform infrared (FT-IR) results suggest that the incorporation of D-AAs favors the molecular stability. The improved properties of Coll-D-AAs matrices can be further manipulated into the functional matrix suitable for the designing of scaffolds. This docking study has provided clear evidence for stabilization of collagen. Coll-D-Lys-wPNs and Coll-D-Lys-cPNs biocomposites were prepared by thermally triggered Coll-D-Lys with preformed wPNs and cPNs and their use as therapeutic drug and gene carriers were studied. The results show increase in the mechanical strength and improved hydrothermal and structural stability. These Coll-D-Lys-PNs biocomposites could be useful in bone and dental implantations and in dura matter defects. newline newline newline
Pagination: xxix, 265
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File16.1 kBAdobe PDFView/Open
02_certificates.pdf1.14 MBAdobe PDFView/Open
03_abstract.pdf30.27 kBAdobe PDFView/Open
04_acknowledgement.pdf17.59 kBAdobe PDFView/Open
05_contents.pdf85.7 kBAdobe PDFView/Open
06_chapter 1.pdf1.11 MBAdobe PDFView/Open
07_chapter 2.pdf2.34 MBAdobe PDFView/Open
08_chapter 3.pdf1.18 MBAdobe PDFView/Open
09_chapter 4.pdf1.06 MBAdobe PDFView/Open
10_chapter 5.pdf947.29 kBAdobe PDFView/Open
11_chapter 6.pdf1.3 MBAdobe PDFView/Open
12_chapter 7.pdf37.85 kBAdobe PDFView/Open
13_references.pdf224.01 kBAdobe PDFView/Open
14_publications.pdf34.06 kBAdobe PDFView/Open
15_vitae.pdf16.11 kBAdobe PDFView/Open

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