Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/152176
Title: Hybrid functional biopolymers as advanced nanocomposite for catalytic drug delivery and sensing applications
Researcher: Gogoi Neelam
Guide(s): Choudhury Devasish
Keywords: Biopolymers
Catalytic drug
Chemistry
Nanocomposite
Sensing application
University: Gauhati University
Completed Date: 2016
Abstract: Nanocomposites offer unique combinations of property and design, a major limitation newlinein the conventional microcomposites. In this class, hybrid functional bionanocomposites newlinehave been introduced as an advanced and versatile generation providing miniaturisation newlineas well as hybridisation between organic and inorganic functions. Be it applications like newlinedrug delivery, sensing or catalysis, these hybrid bionanocomposites on par have proved newlinetheir excellence. newlineIn the thesis, these studies laid the grounds framing the main objective to investigate newlinethe feasibility of three different polysaccharides, viz., chitosan, alginate and agarose to newlineform hybrid bionanocomposites which are variedly functional. The initial work newlineintroduces chitosan gel and tea as two new precursors for the synthesis of carbon dots newline(CD) having particle size less than 10 nm. The CDs from both the sources showed newlinebright blue fluorescence under UV lamp with sharp peaks in their photoluminescence newline(PL) spectra. The unique property variance between these two carbon dots was observed newlinein their net surface charge with chitosan gel CDs showing positive value (and#950;= +27.8 mv), newlineand tea CDs showing negative value (and#950;= 39.2 mV). In addition, the photoluminescent newlineproperties of chitosan CDs at different pH conditions and on incorporation of silver and newlinegold nanoparticles were examined. Interestingly, when chitosan carbon dots combined newlinewith calcium alginate (CA) beads formed a protective coat on the beads. These carbon newlinedots coated alginate beads (CA-CD) showed exceptional stability at room temperature newline(even after 60 days) and also at higher temperature. The CA-CD beads showed their newlineproficiency as a pH dependent drug delivery vehicle taking tetracycline (TC) and newlinetetracycline:and#946;-cyclodextrin (ß-TC) as model drug systems. The TC loading was 35% for newlineCA and 77% for CA-CD, and ß-TC loading was 48% for CA and 90% for CA-CD. A newlinemaximum drug release at pH 1 was obtained with 70% for CA-CD and 37% CA at 96 h. newlineHowever, in case of ß-TC loading the delivery rates were slower showing 61% relea
Pagination: vi, 187 p.
URI: http://hdl.handle.net/10603/152176
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File67.25 kBAdobe PDFView/Open
02_certificate.pdf192.33 kBAdobe PDFView/Open
03_declaration.pdf193.03 kBAdobe PDFView/Open
04_acknowledgement.pdf192.21 kBAdobe PDFView/Open
05_dedication.pdf235.9 kBAdobe PDFView/Open
06_abstarct.pdf204.92 kBAdobe PDFView/Open
07_table of content.pdf393.39 kBAdobe PDFView/Open
08_chapter 1.pdf554.58 kBAdobe PDFView/Open
09_chapter 2.pdf1.85 MBAdobe PDFView/Open
10_chapter 3.pdf1.46 MBAdobe PDFView/Open
11_chapter 4.pdf1.92 MBAdobe PDFView/Open
12_chapter 5.pdf2.55 MBAdobe PDFView/Open
13_chapter 6.pdf1.38 MBAdobe PDFView/Open
14_chapter 7.pdf389.09 kBAdobe PDFView/Open
15_list of publications.pdf225.49 kBAdobe PDFView/Open
16_publications.pdf11.16 MBAdobe PDFView/Open
17_acheivements.pdf35.42 kBAdobe PDFView/Open
18_conference attended.pdf36.7 kBAdobe PDFView/Open


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