Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/145894
Title: MOLECULAR AND IMMUNOLOGICAL CHARACTERIZATION OF ARBOVIRAL INFECTIONS CHIKUNGUNYA AND DENGUE
Researcher: GOPALSAMY S
Guide(s): PADMA SRIKANTH
Keywords: Chikungunya
Dengue
Indian Ocean lineage
Ssevere dengue
Th2 response
Thrombocytopenia
University: Sri Ramachandra University
Completed Date: 01/04/2017
Abstract: Chikungunya samples were collected from northern districts Kasaragod Kannur Kozhikode of Kerala during 2008 and 2009 epidemic Dengue samples were collected from tertiary care center in Chennai Phylogenetic tree constructed using 360 geographic sequences retrieved from GenBank repository revealed that all the study sequences 51 CHIKV positives belong to Indian Ocean lineage IOL of ECSA genotype Within the IOL cluster three distinct clades were formed Over all 7 amino acid substitutions S299N T312M A344T S375T V386G W339R and S375P were observed in that V386G was found in all our study sequences Th2 response was found to be associated with severe dengue Th2 response was also associated with Grade III and Grade IV thrombocytopenia In CHIKV group also non Th1 Th2 IL 8 was elevated in majority of patients 53 n16 Most of the CHIKV patients had joint pain and it was associated with IL8 elevation newline
Pagination: 1-227
URI: http://hdl.handle.net/10603/145894
Appears in Departments:Medical College

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01_title.pdfAttached File85.88 kBAdobe PDFView/Open
02_certificate.pdf256.16 kBAdobe PDFView/Open
03_table of contents.pdf290.33 kBAdobe PDFView/Open
04_list of tables.pdf14.13 kBAdobe PDFView/Open
05_list of figures.pdf96.47 kBAdobe PDFView/Open
06_acknowledgements.pdf20.56 kBAdobe PDFView/Open
07_ introduction.pdf34.1 kBAdobe PDFView/Open
08_review of literature.pdf453.95 kBAdobe PDFView/Open
09_materials and methods.pdf279.68 kBAdobe PDFView/Open
10_results.pdf2.02 MBAdobe PDFView/Open
11_discussion.pdf197.07 kBAdobe PDFView/Open
12_appendices.pdf518.34 kBAdobe PDFView/Open
13_bibliography.pdf256.16 kBAdobe PDFView/Open
14_publications.pdf4.79 MBAdobe PDFView/Open


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