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Title: Study of protective effects of stem bark extracts of ficusracemosa in drug induced nephrogenic diabetes insipidus and nephrotoxicity in animal models
Researcher: Shivalinge Gowda KP
Guide(s): Vrushabendra Swamy B M
Keywords: Pharmacutical Sciences
Nephrogenic diabetes insipidus
Upload Date: 2-Jan-2014
University: Shri Jagdishprasad Jhabarmal Tibarewala University
Completed Date: 17-01-2013
Abstract: The objective of this study was to determine nephroprotective effect on gentamicin, cisplatin, cyclosporine induced nephrotoxicity and lithium induced NDI in animal models. The herbal medicines continue to be the mainstay of healthcare systems and source of livelihoods of many communities in India and other countries. This leads to the increased dependence on medicinal products harvested from natural population. This dependence has led to local extinction of some important medicinal plants that include Ficus racemosa. This study has been designed to explore nephroprotective activity of ethanol and aqueous stem bark extracts (EFR and AFR) of Ficus racemosa in gentamicin, cisplatin, cyclosporine induced nephrotoxicity and lithium induced nephrogenic diabetes insipidus in experimental animals. In gentamicin model after adjustment to the local environment, the rats were taken and divided them randomly to six groups (6 rats/ group). Nephrotoxicity was induced with the administration of gentamicin (80mg/kg i.p.) for 8 days to the second group. The EFR and AFR (200 and 400mg/kg. b.w.) were administered to group III, IV, V, and VI respectively by oral route for three days and continued for another 8 days along with gentamicin. The protective effect was estimated by measuring the kidney weight, urine glucose, urine Na+, urine K+, urine volume, urine creatinine, serum urea, serum creatinine, lipid peroxidation, SOD, catalase, GSH and histopathological examination of kidney tissues in rats. newline newlineThere was an insignificant difference in the weight of the isolated kidneys of the gentamicin induced nephrotoxic rats as compared to the normal rat. The gentamicin, EFR/AFR administered rats also showed an insignificant difference in the weights of the isolated kidneys when compared with gentamicin induced nephrotoxic rats.
Pagination: 176p.
Appears in Departments:Faculty of Pharmacy

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01_title.pdfAttached File18.12 kBAdobe PDFView/Open
02_declaration by the candidate.pdf18.01 kBAdobe PDFView/Open
03_certificate.pdf12.29 kBAdobe PDFView/Open
04_acknowledgement.pdf14.25 kBAdobe PDFView/Open
05_contents.pdf24.09 kBAdobe PDFView/Open
06_list of tables.pdf16.07 kBAdobe PDFView/Open
07_list of figures.pdf21.99 kBAdobe PDFView/Open
08_abbreviations.pdf16.69 kBAdobe PDFView/Open
09_abstract.pdf57.74 kBAdobe PDFView/Open
10_chapter 1.pdf752.57 kBAdobe PDFView/Open
11_chapter 2.pdf1.54 MBAdobe PDFView/Open
12_chapter 3.pdf231.37 kBAdobe PDFView/Open
13_chapter 4.pdf1.6 MBAdobe PDFView/Open
14_chapter 5.pdf27.58 kBAdobe PDFView/Open
15_references.pdf86.64 kBAdobe PDFView/Open

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