Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/139258
Title: FORMULATION AND OPTIMIZATION OF FAST DISSOLVING INTRAORAL DRUG DELIVERY SYSTEMS FOR ANTI EPILEPTIC ACTIVITY
Researcher: Rajni Bala
Guide(s): Dr. Sushil Kumar
Keywords: 
University: Chitkara University, Punjab
Completed Date: 8-4-2016
Abstract: Clobazam is 1, 5 benzodiazepine derivative. It is generally used for the treatment of repeated seizures associated with Lennox syndrome in children s of 2 to 6 year of age. It is safe well tolerated and produce less sedation when compared to the other benzodiazepines. The half life of clobazam is 18 hours. Number of studies estimated the efficacy of clobazam for the treatment of partial and generalized seizures. Clobazam is only prescribed if first line antiepileptic such as phenytoin is unable to control seizures and is taken by mouth once daily to prevent the occurrence of epilepsy. This once daily administration is possible due to long half life of clobazam which lead to patient compliance in epileptic attack as compared to phenytoin to be taken up to four times per day. One of the major factor determining patient s compliance is the use of non invasive drug delivery system. As the development a new drug molecule is time consuming and costly affair, the research is being concentrated on the development new dosage forms of the existing drug molecules for having better patient acceptance and compliance, this approach provided an option for the utilization of intra oral drug delivery systems. Intra oral drug delivery system has several advantages as compared to traditional systems such as fast dissolution, quick absorption through oral mucosa and allowing complete disintegration before swallowing for quick therapeutic action. Thus in this research project , the intra oral fast dissolving systems of clobazam (tablets and films) have been attempted to explore the benefits of such delivery system over the conventional system. newline1. The study began with the preformulation characterization of drug which involves determination of melting point and development of suitable analytical method for the estimation of drug. The most suitable technique was found to UV spectrophotometric method of analysis with r2 value of 0.993 newline
Pagination: 
URI: http://hdl.handle.net/10603/139258
Appears in Departments:Faculty of Pharmacy

Files in This Item:
File Description SizeFormat 
cover page.docxAttached File20.67 kBMicrosoft Word XMLView/Open
front pages.docx60.92 kBMicrosoft Word XMLView/Open
introduction.docx1.42 MBMicrosoft Word XMLView/Open
literature review.docx183.05 kBMicrosoft Word XMLView/Open
material and methods.docx1.01 MBMicrosoft Word XMLView/Open
references.docx56.86 kBMicrosoft Word XMLView/Open
results and discussion.docx3.13 MBMicrosoft Word XMLView/Open
summary and conclusion.docx30.03 kBMicrosoft Word XMLView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.