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Title: Identification of Genetic signatures in high altitude stress
Researcher: Srivastava, Swati
Guide(s): Saradhi, Pardha
Keywords: Environmental science
Acute Mountain Sickness
high altitude stress
genetic signatures
Hypoxia sensing
Upload Date: 4-Dec-2013
University: University of Delhi
Completed Date: 2012
Abstract: Securing the country s borders is the fundamental requirement for maintaining sovereignty of any independent Nation. Army troops are positioned to high altitude like Siachen and Kargil sectors. Despite of adverse conditions (viz. reduced oxygen availability, UV radiations, high velocity dry, cold wind) positioning of soldiers in those areas is extremely important for security of the country. It is important that individuals of military and paramilitary forces posted at high altitude maintain good health and perform extremely well. However, it is well known that the potential to withstand and acclimatize to adverse multiple stress conditions prevailing at high altitude vary from individual to individual. Variation in genetic makeup and gene expression makes individuals to be either susceptible or tolerant to adverse environmental factors. The present investigations elaborates the comparison in gene expression patterns of sensitive sojourns acutely inducted to high altitude from tolerant control and high altitude natives. Blood from human volunteer donors were used for evaluating variation in gene expression. Human whole genome array 40K chips with single fluorescent dye Cy3 were used to study gene expression. It was possible to demonstrate for the first time that the genes for endothelin converting enzyme1, NADPH oxidase1, DnaJ (Hsp40), Hsp 90, IL11, carbonic anhydrase IX, tumor necrosis factor, acetoacetyl CoA synthetase etc. play a critical role in adaptation of individuals to the adverse conditions. Also, HAPE patients showed transcript abundance for genes involved in detoxification and drug metabolism (PEX10, CYP4A11), pyruvat6e metabolism (PDK1), lipid metabolism, carbohydrate metabolism, apoptosis, protein phosphorylation, DNA repair, cell proliferation, differentiation and inflammation. It is evident that alteration in gene expression profile may be critical for the system to acclimatize to hypoxia.
Pagination: v,181p.
Appears in Departments:Dept. of Electronic Science

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01_title.pdfAttached File21.57 kBAdobe PDFView/Open
02_certificate.pdf27.36 kBAdobe PDFView/Open
03_declaration.pdf25.75 kBAdobe PDFView/Open
04_preface.pdf36.33 kBAdobe PDFView/Open
05_acknowledgement.pdf27.18 kBAdobe PDFView/Open
06_content.pdf90.5 kBAdobe PDFView/Open
07_list of tables & figures.pdf44.08 kBAdobe PDFView/Open
08_abbreviations.pdf25.92 kBAdobe PDFView/Open
09_chapter 1.pdf65.14 kBAdobe PDFView/Open
10_chapter 2.pdf600.89 kBAdobe PDFView/Open
11_chapter 3.pdf621.34 kBAdobe PDFView/Open
12_chapter 4.pdf1.54 MBAdobe PDFView/Open
13_chapter 5.pdf1.29 MBAdobe PDFView/Open
14_references.pdf559.59 kBAdobe PDFView/Open
15_appendix.pdf208.2 kBAdobe PDFView/Open
16_abstract.pdf46.83 kBAdobe PDFView/Open
17_plates.pdf4.24 MBAdobe PDFView/Open
18_synopsis.pdf140.76 kBAdobe PDFView/Open

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