Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/134504
Title: THE EFFICACY OF PROTEASOME INHIBITOR AM114 ON NF kB SIGNAL TRANSDUCTION PATHWAY IN RHEUMATOID ARTHRITIS
Researcher: CHITRA.S
Guide(s): NALINI GANESAN
Keywords: AM114
Apoptosis
Macrophages
NFkB
Proteasome inhibitor
Rheumatoid arthritis
University: Sri Ramachandra University
Completed Date: 04/02/2017
Abstract: Rheumatoid arthritis RA is one of the common autoimmune diseases with chronic inflammatory synovitis with cartilage and bone destruction The proinflammatory cytokine interleukin 1beta IL-1and#946; plays a pivotal role in the pathogenesis of RA by activating NFkB pathway The use of Proteasome inhibitors PI in the treatment of autoimmune disease are still at an early stage Inhibition of proteasome function by PI plays an important role in the induction of apoptotic signals and antiinflammatory responses in macrophages The proteasome inhibitor AM114 is a boronic chalcone derivative exerts anticancer activity The present study has explored the effect of AM114 in comparison with aspirin on NFkB signal transduction pathway in IL1and#946; stimulated macrophages derived from HI RA and THP1 cells. Our results showed that AM114 could decrease the production of proinflammatory cytokines chemokines and MMP13 secreted by IL1and#946; stimulated RA and THP1 cells. In addition AM114 has a capacity to induce macrophage apoptosis It also exerts the stabilization of IkB and prevents NFkB p65 nuclear translocation suggesting that AM114 has potent antiinflammatory activity through its inhibitory effects on cytokines by regulating the NFkB pathway The results of this study suggest the use of AM114 as a therapeutic candidate in inflammatory diseases, such as RA newline
Pagination: 1-209
URI: http://hdl.handle.net/10603/134504
Appears in Departments:College of Biomedical Sciences

Files in This Item:
File Description SizeFormat 
01-title.pdfAttached File83.57 kBAdobe PDFView/Open
02-certificate.pdf778.21 kBAdobe PDFView/Open
03-acknowledgements.pdf132.23 kBAdobe PDFView/Open
04- contents.pdf94.74 kBAdobe PDFView/Open
05-list of figures and tables.pdf157.18 kBAdobe PDFView/Open
06-abbreviations.pdf155.83 kBAdobe PDFView/Open
07-introduction.pdf906.64 kBAdobe PDFView/Open
08- review of literature.pdf192.85 kBAdobe PDFView/Open
09-methodology.pdf1.35 MBAdobe PDFView/Open
10-results.pdf2.25 MBAdobe PDFView/Open
11-discussion.pdf221.58 kBAdobe PDFView/Open
12-conclusion.pdf254.43 kBAdobe PDFView/Open
13-summary.pdf171.93 kBAdobe PDFView/Open
14-future research.pdf93.24 kBAdobe PDFView/Open
15-references.pdf294.54 kBAdobe PDFView/Open
16-appendix.pdf195.18 kBAdobe PDFView/Open
17-publications.pdf221.13 kBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetric Badge: