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Title: Study on synthesis of chalcone and pyrimidine heterocyclic compound and their antimicrobial activity
Researcher: Patel, Rajarshi N
Guide(s): Vyas, Kartik B
Keywords: Chemistry
Antimicrobial activity
Pyrimidine heterocyclic compound
Upload Date: 28-Nov-2013
University: Shri Jagdishprasad Jhabarmal Tibarewala University
Completed Date: 14/12/2012
Abstract: The principal of this thesis is One of our aims in research has been the development of new tools and methodologies for drug discovery. The molecular manipulation of promising lead compounds is still a major line of approach to develop new and efficient drugs. In the present study, we undertook the total synthesis of several Chalcones and derivatives of Chalcone. 4-Chloroaniline reacts with 1-(3-hydroxyphenyl)-ethanone in presence of 1-napthonic acid and copper metal as a catalyst (Ullmann reaction) gives 1-(3-(4-aminophenoxy) phenyl) ethanone, which on further condensation with 4-nitrotoluene-2-sulfonylchloride gives N-(4-(3-acetylphenoxy) - phenyl)-2-methyl-5-nitrobenzene -sulphonamide. N-(4-(3-acetylphenoxy)phenyl)-2-methyl-5-nitrobenzenesulphonamide is condensed with different substituted aryl aldehydes at 0 to 5°C using 40% NaOH. The time required for completion of the reaction was 18 to 24 hours. The chalcone produced where yellow, orange and red in color, light weighted and in good yield.
Pagination: 168p.
Appears in Departments:Faculty of Sciences

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01_title.pdfAttached File52.65 kBAdobe PDFView/Open
02_declaration.pdf54.07 kBAdobe PDFView/Open
03_certificate.pdf47.17 kBAdobe PDFView/Open
04_acknowledgement.pdf62.04 kBAdobe PDFView/Open
05_table of content .pdf38.84 kBAdobe PDFView/Open
06_list of tables.pdf41.2 kBAdobe PDFView/Open
07_list of figures.pdf38.3 kBAdobe PDFView/Open
09_abbrivations.pdf27.62 kBAdobe PDFView/Open
10_abstract.pdf70.13 kBAdobe PDFView/Open
11_ chapter 1.pdf607.18 kBAdobe PDFView/Open
12_chapter 2.pdf440.23 kBAdobe PDFView/Open
13_ chapter 3.pdf288.45 kBAdobe PDFView/Open
14_chapter 4.pdf274.08 kBAdobe PDFView/Open
15_ chapter 5.pdf327.29 kBAdobe PDFView/Open
16_ chapter 6.pdf272.38 kBAdobe PDFView/Open
17_ chapter 7.pdf329.98 kBAdobe PDFView/Open
18_ chapter 8.pdf319.18 kBAdobe PDFView/Open
19_ chapter 9.pdf307.31 kBAdobe PDFView/Open
20 _chapter 10.pdf831.67 kBAdobe PDFView/Open
21_ chapter 11.pdf1.64 MBAdobe PDFView/Open
22_ results and discussions.pdf81.98 kBAdobe PDFView/Open
23_ references .pdf114.93 kBAdobe PDFView/Open

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