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Title: Formulation and development of Pulsatile drug delivery systems PDDS
Researcher: Shinde, Prashant Vishwas
Guide(s): Mayee, Rahul V
Keywords: Pharmaceutical sciences
Upload Date: 26-Nov-2013
University: Shri Jagdishprasad Jhabarmal Tibarewala University
Completed Date: 28-06-2013
Abstract: The principal of this thesis is newlineNow a day there is increase interest in academics as well as industrial research groups in novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time. newlinePulsatile drug delivery systems are gaining a lot of interest now days. These systems are designed according to the circadian rhythm of the body. These systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient compliance and therapeutic efficacy. Which is meant as the liberation of drugs following programmed lag phases, has drawn increasing interest, especially in view of emerging chronotherapeutic approaches. Pulsatile drug delivery shows rhythms like rheumatoid arthritis, cardiovascular diseases, asthma, peptic ulcer, allergic rhinitis. newlineAceclofenac, a nonsteroidal anti-inflammatory drug, is used for the symptomatic relief of pain and joint stiffness in patients suffering from rheumatoid arthritis, which is characterized by diurnal variation in circulating levels of proinflammatory cytokines, interleukin-6 and/or tumor necrosis factor-and#945;. Due to this diurnal variation, many symptoms and signs of active rheumatoid arthritis are manifested in the morning.7 on oral administration at bed-time, releases Aceclofenac after a desired lag time of about 360 - 420 minutes which corresponds with peak levels of proinflammatory mediators. newlineThe objective of this work was to develop current study illustrates the formulation, characterization, and optimization of press coated tablet,. floating-pulsatile drug delivery system and Formulation development of coated tablet of Aceclofenac by using coating of rupturable layer. Press-coating, also known as compression coating, is relatively simple and cheap, and may involve direct compression of both the core and the coat, obviating the need for a separate coating process and the use of coating solutions. Materials such as hydrophilic cellulose derivatives can be used newline newline
Pagination: --
Appears in Departments:Faculty of Pharmacy

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01_title page.pdfAttached File11.97 kBAdobe PDFView/Open
02_declaretion.pdf136.89 kBAdobe PDFView/Open
03_certificates.pdf123.3 kBAdobe PDFView/Open
04_acknowledgement.pdf346.99 kBAdobe PDFView/Open
05_list of table.pdf492.45 kBAdobe PDFView/Open
06_list of figures.pdf411.63 kBAdobe PDFView/Open
07_abstarct.pdf28.11 kBAdobe PDFView/Open
08_chapter 1intoduction.pdf347.4 kBAdobe PDFView/Open
09_chapter 2experimental.pdf129.97 kBAdobe PDFView/Open
10_chapter 3result and discussion.pdf1.33 MBAdobe PDFView/Open
11_chapter 4summary and conclusion.pdf32.18 kBAdobe PDFView/Open
12_references.pdf90.96 kBAdobe PDFView/Open
13_annexures publication.pdf26.57 kBAdobe PDFView/Open

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