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Title: Relation of metabolic syndrome with inflammatory markers in non-diabetic first degree relatives of type 2 diabetes patients
Researcher: Manjrekar, Poornima
Guide(s): Raghuveer C V
D'Souza, Vivian
Adhikari, Prabha
Keywords: Biotchemistry
Type2 Diabetes
Metabolic syndrome
Inflammatory markers
Upload Date: 20-Nov-2013
University: Manipal University
Completed Date: 15/11/2012
Abstract: Vulnerability to type2 diabetes is inherited, but its overt appearance is affected by medical, social and behavioral factors. It develops gradually over decades, with a long prediabetic interval of mild, moderate or intermittent hyperglycemia. The complexity of the natural history of type 2 diabetes and the high variability in its clinical presentation often results in about a decade s delay before the diagnosis is made. A strong familial aggregation is observed among Asian Indians with high prevalence among the first degree relatives (FDRs). newlineAlthough genetic predisposition largely governs the occurrence of type 2 diabetes, the exact molecular basis of defective insulin secretion and reduced tissue response to insulin remains elusive. In about 20% of cases, diabetic complications are seen at the time of initial diagnosis, indicating that the pathology begins much earlier. The exact time is difficult to ascertain and so far, alterations in the plasma glucose concentrations are the earliest markers. The hypothesis that type 2 diabetes could be a disease of the innate immune system is another step towards understanding the pathophysiology of the disease. Deficient insulin secretion and action has also been demonstrated in non-diabetic relatives of newlinepatients with type 2 diabetes. Inflammatory markers like the white blood cell count, CRP, newlineInterleukins, fibrinogen and sialic acid have shown to predict the development of type 2 newlinediabetes.
Pagination: 222p.
Appears in Departments:Molecular Genetics and Biochemistry

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01_title.pdfAttached File33.79 kBAdobe PDFView/Open
02_certificate.pdf38.94 kBAdobe PDFView/Open
03_abstract.pdf70.16 kBAdobe PDFView/Open
04_declaration.pdf20.05 kBAdobe PDFView/Open
05_acknowledgement.pdf27.8 kBAdobe PDFView/Open
06_contents.pdf15.38 kBAdobe PDFView/Open
07_list_of_tables.pdf292.71 kBAdobe PDFView/Open
08_list_of_figures.pdf42.37 kBAdobe PDFView/Open
09_abbreviations.pdf58.76 kBAdobe PDFView/Open
10_chapter 1.pdf60.69 kBAdobe PDFView/Open
11_chapter 2.pdf576.11 kBAdobe PDFView/Open
12_chapter 3.pdf46.96 kBAdobe PDFView/Open
13_chapter 4.pdf104.98 kBAdobe PDFView/Open
14_chapyer 5.pdf40.58 kBAdobe PDFView/Open
15_chapter 6.pdf187.45 kBAdobe PDFView/Open
16_conclusion & summary.pdf64.05 kBAdobe PDFView/Open
17_bibliography.pdf199.98 kBAdobe PDFView/Open
18_annexures.pdf1.52 MBAdobe PDFView/Open

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