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Title: Design and development of novel drug delivery systems for selected drug candidates
Researcher: Reddy, Y Sreenivasa
Guide(s): Dinakar, A
Keywords: drug candidates
novel drug delivery systems
Upload Date: 14-Nov-2013
University: Jawaharlal Nehru Technological University, Anantapuram
Completed Date: 29.04.2013
Abstract: Oral ingestion has been the most convenient and commonly employed route of drug delivery. Controlled drug delivery system for oral dosage forms offer greater advantages in minimizing the dosage frequency and there by the toxicity and improves the patient compliance. These novel drug delivery system control the release of drug by diffusion or erosion or osmosis etc. The present study was to develop stable and robust formulations of Alfuzosin hydrochloride ER tablets 10mg and controlled release tablets of Citicoline 1000 mg. Alfuzosin hydrochloride is used to reduce the symptoms of benign prostatic hyperplasia (BPH).Citicoline is useful in the treatment of ischemic stroke, head trauma and neurodegenerative disease. Design of controlled release drug delivery systems for highly soluble drugs is challenging to pharmaceutical scientists. Various techniques have been proposed in the design of controlled release systems of these moieties. Matrix tablets have gained popularity in the designing of controlled drug delivery systems. But it is difficult to control the release of high soluble drugs by simple matrix system. Hence in the present study we aimed in the preparation of matrix dosage forms for alfuzosin and citicoline by using natural polymer (i.e. Guar gum), synthetic polymers (i.e. HPMC K100 M, HPC - HF, Eudragit RSPO and Eudragit RLPO) alone and in combinati on of polymers. ii In case of alfuzosin we used different concentration of Eudragit RLPO, Guar gum 8000 cP and HPMC K100M alone and combination of HPMC K100M and guar gum 8000 cP. Among all formulations, the formulation B.No:ALF/10 (combination of HPMC K100M and guar gum 8000 cP) showed comparable results with respect to in vitro and in vivo tests, when compared with commercial reference formulation (UROXATRAL). In case of citicoline we used combination of hydrophilic and hydrophobic polymers. Citicoline controlled release tablets were prepared by wet granulation method using non aqueous granulation fluid. The formulation B.No:CTC/14 (Eudragit RSPO- 12.5 % w/w a
Pagination: 214p.
Appears in Departments:Department of Pharmaceutical Sciences

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01 _title.pdfAttached File87.63 kBAdobe PDFView/Open
02_ certificate declaration.pdf114.08 kBAdobe PDFView/Open
03_acknowledgement.pdf132.34 kBAdobe PDFView/Open
04_contents.pdf179.3 kBAdobe PDFView/Open
05_abstract.pdf140.29 kBAdobe PDFView/Open
06 _list of figures & tables.pdf129.9 kBAdobe PDFView/Open
07_chapter 1.pdf300.71 kBAdobe PDFView/Open
08_ chapter 2.pdf170.29 kBAdobe PDFView/Open
09_chapter 3.pdf291.95 kBAdobe PDFView/Open
10_chapter 4.pdf124.81 kBAdobe PDFView/Open
11_ chapter 5.pdf1.17 MBAdobe PDFView/Open
12_ chapter 6.pdf1.1 MBAdobe PDFView/Open
13_chapter 7.pdf1.91 MBAdobe PDFView/Open
14_chapter 8.pdf198.84 kBAdobe PDFView/Open
15_references.pdf243.27 kBAdobe PDFView/Open
16_list of publications.pdf107.53 kBAdobe PDFView/Open

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