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Title: quotAssessment of Beneficial Herb Drug Interactions A Pharmacokinetic Approachquot
Researcher: Hemnath, E
Guide(s): S.Sankar
Keywords: anti-diabetic drugs, metformin, pioglitazone, Cassia auriculata, Trigonellafoenum-graecum, Momordicacharantia, herb drug interaction
University: JSS University
Completed Date: 03/04/2015
Abstract: quotThe study focused on interaction of anti-diabetic drugs viz. pioglitazone and metformin with culinary herbs. It is necessary to understand the PK and PD of the drug action in the presence/absence of the herbal drug in order to select a phytochemical that could act in synergy with allopathic drug and beneficial outcome in combination therapy of few commonly used herbal drugs (culinary). Effect of blood glucose levels were monitored at two different dose levels for Metformin and Pioglitazone with combination with Cassia auriculata L., Trigonellafoenum-graecum,Momordicacharantia L. Both allopathic drugs (metformin and pioglitazone) herbs. Cassia auriculataL., Trigonella foenum-graecum,Momordicacharantia L. showed significant blood glucose lowering effect when given alone under these experimental conditions. Combination of Trigonellafoenum-graecum with metformin and pioglitazone, and Momordicacharantia L. with pioglitazone significantly reduced the blood glucose levels compared to other combinations and the lower dose of allopathic drug treated had a similar glucose lowering effect when compared with drug alone treated group. Noticeable changes in PK parameters were observed in combination of metformin with Cassia auriculataL., and pioglitazone with Momordicacharantia L., where reduction of dose could exhibit the similar PK parameters as that of drug alone treated. Other treatment groups did not show any significant alteration in PK. newlineOverall long term use of allopathic drugs to cause undesirable effects and risk of herb drug interactions have been addressed by reduction of allopathic drug dose in combination therapy though PK/PD. The problems that still need to be addressed are constancy, selectivity and bioavailability of these herbal products, dosing strategy and any adverse herb drug interaction and PK/PD Correelaion newline newline
Pagination: I-X, 1-91P
Appears in Departments:College of Pharmacy

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01_title.pdfAttached File117.27 kBAdobe PDFView/Open
02_certificates.pdf200.37 kBAdobe PDFView/Open
03_acknowledgements.pdf31.75 kBAdobe PDFView/Open
04_contents.pdf66.6 kBAdobe PDFView/Open
06_chapter 1.pdf313.98 kBAdobe PDFView/Open
07_chapter 2.pdf731.43 kBAdobe PDFView/Open
09_chapter 4.pdf213.12 kBAdobe PDFView/Open
10_chapter 5.pdf411.78 kBAdobe PDFView/Open
11_chapter 6.pdf1.13 MBAdobe PDFView/Open
12_chapter 7.pdf246.02 kBAdobe PDFView/Open
15_references.pdf302.71 kBAdobe PDFView/Open

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