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Title: Synthesis and physicochemical studies of metal complexes and metal encapsulated complexes
Researcher: Shabana Noor
Guide(s): Zafar Ahmad Siddiqi
Keywords: Chemistry
Upload Date: 12-Nov-2013
University: Aligarh Muslim University
Completed Date: n.d.
Abstract: The study of the interaction of transition and heavy metal ions with naturally occurring organic moieties which serve as potent chelating agents has been considered attractive to inorganic and bioinorganic chemists, specially for evaluating important beneficial or deteriorative effects of these metal ions in the living systems. Pyridineand#8722;2, 6 and#8722;dicarboxylic acid trivial name dipicolinic acid, is present in nature as an oxidative degradation product of vitamins, coand#8722;enzymes and alkaloids and is a component of fulvic acid. It has been found to act as a water germicidal agent and antioxidant for ascorbic acid in fruits. It is a versatile and desirable metal ion chelator exhibiting low toxicity and amphophilic nature. Many transition metal complexes with dicarboxylate ligands have been exploited as possible future drugs for many diseases. The recent reports in the development of metal based drugs incorporating suitable organic moieties indicate that a class of the organic ligands modify the metal ion chemistry to such an extent that the resulting metal complexes can be exploited as effective drugs with decreased toxic effects. The most interesting examples are the Vanadium complexes which have been used effectively as insulin mimics (antidiabetic drugs). Most of the compounds reported in this regard contain polydentate ligands preferably with functionalized di and tri- carboxylate moieties and the resulting complexes have 1:2 metal to ligand stoichiometry. The functionalized carboxylic acids as for example picolinic acid acid (H2PDA), iminodiacetic acid (H2IDA), oxydiacetic acid (H2ODA), nitrilotriacetic acid (H3NTA) and ethylenetriamine tetraacetic acid (H4EDTA) have been considered as potent chelating ligands for such investigations. The coordination chemistry of these functionalized polycarboxylic acid ligands has been a centre stage for inorganic and bioinorganic chemists over the past decades. These ligands constitute of an important class of polydentate [N,O,O] or [O,O,O] chelators.
Pagination: 147p.
Appears in Departments:Department of Chemistry

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01_certificate.pdfAttached File73.3 kBAdobe PDFView/Open
02_dedication.pdf60.78 kBAdobe PDFView/Open
03_abstract.pdf64.88 kBAdobe PDFView/Open
04_acknowledgement.pdf12.26 kBAdobe PDFView/Open
05_contents.pdf45.5 kBAdobe PDFView/Open
06_chapter 1.pdf605.67 kBAdobe PDFView/Open
07_chapter 2.pdf289.96 kBAdobe PDFView/Open
08_chapter 3.pdf208.51 kBAdobe PDFView/Open
09_chapter 4.pdf1.66 MBAdobe PDFView/Open
10_chapter 5.pdf230.89 kBAdobe PDFView/Open
11_publications.pdf13.7 kBAdobe PDFView/Open
12_published paper.pdf454.3 kBAdobe PDFView/Open

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