Studies on metal complexes of novel ligand system

Abstract

The interaction of metal ions with naturally occurring organic chelating moieties has been a centre stage of research for inorganic and bioinorganic chemists. The chemistry of mixed ligands or ternary complexes has recently attracted attention of researchers because such complexes have important structural diversities as well as biological applications. Ternary complexes containing aminoalcohols or their derivatives as primary ligand and N- donor heterocyclic ligands like pyridine, phenanthroline, bipyridine and their substituted analogues as auxiliary ligand have been considered useful models for several mono and poly-metallic enzymes or biosites. The flexible aminoalcohols like Hmea (monoethanolamine), Hpa (propanolamine), H2dea (diethanolamine), and H3tea (triethanolamine) are among the potential candidates capable to produce different kinds of polynuclear complexes. Although a large number of transition metal complexes of chelating polyamines have been reported, relatively few complexes of chelating aminoalcohols have been isolated. The mono-, di-, or polynuclear coordination complexes of amino alcohols as primary ligand and N-chelator as secondary ligands have been synthesized and characterized employing modern spectral techniques like IR, FAB and ESI-Mass, NMR, Mand#1255;ssbauer, EPR, UV-visible and of possible X-ray crystallography. Their biological activities (like antimicrobial, SOD and genotoxic properties) have also been discussed and correlated with various structural factors of the novel molecules synthesized. The thesis contains five Chapters as follows: newlineChapter I deals with the general introduction and review on the chemistry of transition metal binary and ternary complexes incorporating aminoalcohols asprimary chelating agent. The coordination chemistry of aminoalcohol ligands has attracted inorganic and bioinorganic chemists due to the flexibility of these ligands which makes them useful for the formation of the complexes differing in coordination numbers, conformations and 3-D architectures.