Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/127377
Title: Evaluation of corticosteroid vitamin D combination in asthma
Researcher: Agrawal, Ashok Dilipkumar
Guide(s): Mehta, Anita A
Keywords: Asthma
Vitamin D
corticosteroid
University: Gujarat Technological University
Completed Date: May/2016
Abstract: Asthma is a chronic inflammatory lung disease characterized by inflammation of the airways, increased mucous production, and airway hyperresponsiveness. Airway inflammation and narrowing of airway passages lead to wheezing, coughing, chest tightness and shortness of breath. A hallmark feature of asthma is the presence and activation of inflammatory cells in the airways, notably eosinophils, basophils, mast cells, and T lymphocytes. The mast cells in the airways have the potential to release asthmatic mediators such as histamine, tryptases, chymases and various other enzymes, and cytokines. Current asthma treatments are based on inhaled corticosteroids, long and short acting and#946;2-adrenoreceptor agonists as well as leukotriene antagonists. Inhaled corticosteroid has become first-line treatment for most of the patients. However; long term use of corticosteroid is known to induce various side effects like hyperglycemia, hypertension, cardiometabolic abnormalities, psychiatric adverse effects, weight gain and osteoporosis. Moreover, chronic use of corticosteroid induces vitamin D deficiency and low level of vitamin D contributes to increase in asthma severity. newline newline
Pagination: 8.49 MB
URI: http://hdl.handle.net/10603/127377
Appears in Departments:Pharmacy

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01_title page.pdfAttached File11.34 kBAdobe PDFView/Open
02_certificate.pdf191.61 kBAdobe PDFView/Open
03_abstract.pdf232.26 kBAdobe PDFView/Open
04_declaration..pdf179.89 kBAdobe PDFView/Open
05_acknowledgement..pdf92.62 kBAdobe PDFView/Open
06_contents..pdf22.22 kBAdobe PDFView/Open
07_list_of_tables.pdf14.62 kBAdobe PDFView/Open
08_list_of_figures.pdf138.84 kBAdobe PDFView/Open
09_abbreviations.pdf154.91 kBAdobe PDFView/Open
10_introduction.pdf228.44 kBAdobe PDFView/Open
12_review of literature.pdf1.7 MBAdobe PDFView/Open
13_materials and methods.pdf479.35 kBAdobe PDFView/Open
14_results.pdf4.37 MBAdobe PDFView/Open
15_discussion.pdf437.12 kBAdobe PDFView/Open
16_conclusion.pdf82.8 kBAdobe PDFView/Open
17_references.pdf367.28 kBAdobe PDFView/Open


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