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Title: STUDIES ON THE ANTI ARTHRITIC ACTIVITY OF SELECTED SPECIES OF SEAWEEDS Sargassum ilicifolium Turner C Agardh AND Gelidiella acerosa Forsskal Borgesen FROM GULF OF MANNAR
Researcher: R. Lavanya
Guide(s): S. Seethalakshmi
Keywords: Antiarthritic
Crude sulphated Polysaccharide
Gelidiella Acerosa
Sargassum ilicifolium
University: Sri Ramachandra University
Completed Date: 02/11/2016
Abstract: Seaweeds have been used as food fodder fertilizer and as source of medicine The seaweeds from Gulf of mannar have been less explored for antiarthritic activity The red algae Gelidiella acerosa and brown algae Sargassum ilicifolium selected for this study have been reported to have bioactive principles The crude sulphated polysaccharide isolated from Sargassum ilicifolium against Complete Freunds adjuvant induced arthritis was carried out in Sprague Dawley rats The results revealed that the low dose of crude sulphated polysaccharide 5mg per kg significantly inhibited proinflammatory cytokines like TNF IL2 and CD4 cells and expressed antiinflammatory cytokine TGF than the high dose 10mg per kg It can be concluded that 5 mg per kg of crude fucose containing sulphated polysaccharide from marine brown algae Sargassum ilicifolium is an effective anti arthritic drug mediating its effect through cytokine pathway and this is the first ever report from this Seaweed species from Gulf of Mannar newline
Pagination: 1-225
Appears in Departments:College of Pharmacy

Files in This Item:
File Description SizeFormat 
01.title.pdfAttached File50.05 kBAdobe PDFView/Open
02.certificate.pdf31.96 kBAdobe PDFView/Open
03.contents.pdf150.96 kBAdobe PDFView/Open
04.list of tables.pdf98.29 kBAdobe PDFView/Open
05.list of figures.pdf148.23 kBAdobe PDFView/Open
06.abbrevations.pdf147.99 kBAdobe PDFView/Open
07.acknowlegment.pdf133.96 kBAdobe PDFView/Open
08.introduction.pdf579.27 kBAdobe PDFView/Open
09.aim and objectives.pdf135.54 kBAdobe PDFView/Open
10. about the seaweed.pdf272 kBAdobe PDFView/Open
11. review of literature.pdf236.77 kBAdobe PDFView/Open
12. plan of work.pdf168.07 kBAdobe PDFView/Open
13. physicochemical analysis of seaweeds.pdf223.99 kBAdobe PDFView/Open
14. phytochemical analysis.pdf530.29 kBAdobe PDFView/Open
15. invitro pharmacological evaluation of various extracts.pdf358.94 kBAdobe PDFView/Open
16.chromatographic analysis.pdf241.86 kBAdobe PDFView/Open
17. isolation of lead molecule.pdf88.02 kBAdobe PDFView/Open
18. phytochemical and spectral analysis of crude sulphated polysaccharide.pdf514.11 kBAdobe PDFView/Open vitro pharmacological evaluation of isolated crude sulphated polysaccharide.pdf333.16 kBAdobe PDFView/Open
20. in vivo pharmacological evaluation of isolated crude sulphated polysaccharide.pdf2.46 MBAdobe PDFView/Open
21. summary.pdf95.9 kBAdobe PDFView/Open
22. conclusion.pdf46.7 kBAdobe PDFView/Open
23. future persepctives.pdf51.04 kBAdobe PDFView/Open
24.appendix.pdf1.8 MBAdobe PDFView/Open
25.publications.pdf5.29 MBAdobe PDFView/Open
26.errata.pdf16.98 kBAdobe PDFView/Open

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