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Title: Gene Expression Profiling and Genetic Variations in Oral Cancer Associated with Tobacco Consumption
Guide(s): Dr. Sujala Kapur
Keywords: Gene
Oral Cancer
University: Birla Institute of Technology and Science
Completed Date: 1/7/2012
Abstract: Oral cancer is the sixth most common cancer worldwide, accounting for 4% of newlinecancers in men and 2% of cancers in women. Annually, over 300,000 new cases of oral newlinecancer are diagnosed all over the world where the majority of them are diagnosed in the advanced stages III or IV. Such data make the oral cancer an important public health problem which is responsible for 3% to 10% of cancer mortality worldwide. There is upto a 20 fold newlinegeographical variation in the incidence rates of oral cancer. In India oral cancer is the most common cancer among men and ranks third among women, with age-standardized incidence rates of 12.8 and 7.5 per 100,000 population respectively. Northeastern states in India have newlinereported a very high prevalence of oral cancer. In this region there is widespread chewing habit of tobacco with peculiarly fermented betel nut. This study is based on oral cancer samples collected from three regional collaborating centers (Guwahati, Sikkim and Aizawl)of Northeast (NE) India. These are the Population Based Cancer Registry (PBCR) centers located in NE India which were in collaboration with our Institute for five years (2005-2010), newlineand provided samples for this study. Knowledge of cancer genetics is rapidly improving our understanding of cancer biology, helping to identify at-risk individuals, furthering the ability newlineto characterize malignancies, establishing treatment tailored to the molecular fingerprint of the disease, and leading to the development of new therapeutic modalities. Given the poor prognosis associated with oral cancer, there is an urgent need to elucidate the molecular newlinedeterminants and critical signal pathways underlying the malignant transformation of newlineprecancerous to cancerous tissue which may lead to identification of novel diagnostic and therapeutic targets.
Pagination: 6MB
Appears in Departments:Biological Science

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