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Title: Design and Evaluation of Oral Delivery Systems for Biologically Active Macromolecules Insulin
Keywords: Insulin, Active Macromolecules
University: Birla Institute of Technology and Science
Completed Date: 
Abstract: Delivering protein and peptides by the oral route is extremely challenging due to very nature of the digestive system designed to break down these polypeptides into amino acids prior to absorption and very poor permeability of gut wall for hydrophilic large molecules like proteins and peptides. Variety of approaches have emerged in the recent past for designing oral delivery systems for therapeutic proteins and peptides, although a clinically viable solution to this long standing problem still alludes the scientific community. These approaches come from such diverse research disciplines as biomaterials, conjugation chemistry, nanotechnology, cell biology, and employ different methodologies for solving the same problem. Some of these strategies have distinguishing beneficial characteristics that make them good candidates for oral protein delivery. Interfacing different strategies to combine the benefits of novel approaches is an interesting new possibility. Despite extensive research in this area, a successful oral delivery systems of proteins and peptides especially large macromolecules, like insulin is yet to see the successful commercial product. newlineDiabetes mellitus is occurring in epidemic proportions in many developing and newly industrialized countries. Globally, it is now one of the most common non-communicable diseases and is the fourth or fifth leading cause of death in most developed countries. The global burden of diabetes is estimated to rise from about 118 million in 1995 to 220 million in 2010 and 300 million in 2025. newlineOral delivery formulation for insulin is highly desirable from a patient compliance point of view and other considerations discussed above. However, only a small portion of insulin administered orally reaches the blood stream, mainly due to extensive degradation of the protein in the gastrointestinal tract. Further, large size and hydrophilicity of the molecule greatly limits its transport across the intestinal epithelium. No specific transport mechanism is present for the passage of
Pagination: 2.45 MB
Appears in Departments:Pharmacy

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