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Title: Design and Evaluation of Mucoadhesive Buccal Delivery Systems of Lercanidipine Hydrochloride
Keywords: Mucoadhesive Buccal, Lercanidipine Hydrochloride.
University: Birla Institute of Technology and Science
Completed Date: 
Abstract: The objective of this work was to design and evaluate mucoadhesive buccal tablets newlineof lercanidipine hydrochloride. To achieve this broad objective analytical methods for newlineaccurate and precise estimation of drug in variety of samples were developed. Extensive newlinepreformulation studies were carried out for establishing pharmaceutically relevant newlinephysicochemical properties of the drug. Buccal mucoadhesive controlled release tablets of newlinethe drug were prepared and evaluated for in vitro and in vivo performance. newlineFormulations were prepared using various mucoadhesive and rate controlling newlinepolymers either alone or in combination using direct compression technique. Effect of ionic newlinenature, hydrophilicity/ hydrophobicity and swelling behavior of the polymer on in vitro drug newlinerelease and mucoadhesion was assessed. Designed formulations were characterized for drug newlinecontent, weight variation, friability, thickness and hardness. Further, in vivo studies of newlineselected formulations were carried out in rabbits to establish the bioavailability relative to newlineoral dose. In vivo human acceptability studies were carried out for assessing compatibility newlineand acceptability of designed formulations in humans. newlineResults indicated that all the developed and validated methods were accurate and newlineprecise and facilitated estimation of drug in variety of samples. Preformulation studies newlineindicated poor solubility of drug with high partition coefficient. Drug was found to be newlinephotosensitive in solution and solid state stability studies. Drug was compatible with all the newlineselected excipients. newlineThe designed tablets possessed good physical characteristics with acceptable weight newlinevariation and good content uniformity. The designed formulations were stable for at least newlinetwo years when stored at controlled room temperature. Drug release and mucoadhesive newlinebehavior of designed tablets was affected by polymer proportion, polymer combination, newlinepolymer hydrophilicity/ hydrophobicity and swelling behavior of the polymer.
Pagination: 1.70MB
Appears in Departments:Pharmacy

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